Welcome to this mind-boggling collection of 50 fantastic 16 x 16 sudoku puzzles. 16 x 16 sudoku puzzles work just the same as regular 9 x 9 sudoku puzzles, but they are, well, a lot bigger Infact whereas a normal sudoku has 81 squares in it, a 16x16 sudoku has 256 squares in it, so you get a lot more puzzle for your money. Here are the rules of 16 x 16 sudoku: - Place each number from 1 - 16 exactly once in each row, column and 4x4 bold-lined box that compose the grid.