β3 Adrenoreceptor: Pharmaceutical Science Series
Editat de A. Donny Strosbergen Limba Engleză Hardback – 20 iul 2000
In addition to the major interest in obesity and diabetes expressed by the pharmaceutical industry, increasing numbers of academic groups are attracted by this general research area. This renewed interest is of course in part stimulated by available financing from industry. It also reflects the growing realisation that metabolism remains an open frontier: little is known about adipocyte sub-populations, specific markers, or endocrine functions. Research on the ß3 adrenoreceptor and discussion about the hypothetical ß4 adrenoreceptor is currently stimulating considerable interest which will certainly be satisfied by this volume. The Beta-3 Adrenoreceptor will appeal to readers at graduate and post-graduate levels of all major universities and other research and education institutes.
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Specificații
ISBN-13: 9780748408047
ISBN-10: 0748408045
Pagini: 188
Dimensiuni: 174 x 246 x 20 mm
Greutate: 0.49 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
Seria Pharmaceutical Science Series
ISBN-10: 0748408045
Pagini: 188
Dimensiuni: 174 x 246 x 20 mm
Greutate: 0.49 kg
Ediția:1
Editura: CRC Press
Colecția CRC Press
Seria Pharmaceutical Science Series
Public țintă
ProfessionalCuprins
Introduction - Structure and Function of the ß3-Adrenoreceptor. Regulation of the ß3-Adrenoreceptor Signalling Efficacy. Using Transgenic and Gene Knockout Techniques to Assess ß3-Adrenoreceptor Function. ß3-Adrenoreceptor Ligands and the Pharmacology of ß3-Adrenoreceptor. The Native Human ß3-Adrenoreceptor. ß3-Adrenoreceptor-Mediated Responses in Heart and Vessels. ß3-Adrenoreceptors in Brown and White Adipocytes: Roles in Thermogenesis and Energy Balance. The Putative "ß4"-Adrenoreceptor and Other Atypical ß-Adrenoreceptors.
Descriere
Since the first pharmacological description of an 'atypical' ß-adrenoreceptor and the cloning of the ß3AR gene, research interest in this receptor has grown considerably and many advances have been made in describing various properties of the ß3AR and its ligands. Thanks to the lipolytic activity of ß3AR ligands, several of these compounds have now entered clinical trials. Moreover, genotyping for the presence of a polymorphism in the ß3AR gene, possibly associated with increased risk of developing diabetes and/or obesity has become one of the possible targets for pharmacogenomic approaches to treat these growing health problems.
The ß3-adrenoreceptor covers all the latest developments in the field. It begins with a general overview on the structure, function and expression of the ß3AR before discussing regulation of the receptor and the consequences of ß3AR gene knockout. A detailed description of the receptor's pharmacology and functional role in humans is also given, followed by an account of it's lesser-known vasodilatory role. Throughout, the ß3AR is placed in context by reference to ß1AR and ß2AR homologues as well as the more recently described, still putative, fourth ßAR
Suitable for researchers from industry and academia, this timely book presents a clear and complete description of the ß3AR, with contributions from many of those involved in ß3AR research from the beginning.
The ß3-adrenoreceptor covers all the latest developments in the field. It begins with a general overview on the structure, function and expression of the ß3AR before discussing regulation of the receptor and the consequences of ß3AR gene knockout. A detailed description of the receptor's pharmacology and functional role in humans is also given, followed by an account of it's lesser-known vasodilatory role. Throughout, the ß3AR is placed in context by reference to ß1AR and ß2AR homologues as well as the more recently described, still putative, fourth ßAR
Suitable for researchers from industry and academia, this timely book presents a clear and complete description of the ß3AR, with contributions from many of those involved in ß3AR research from the beginning.