This open access book celebrates the decennial of the Department of Industrial Engineering of Università di Napoli Federico II, Italy. It covers the main research achievements developed at the department in the fields of aerospace, marine, energy, statistical, mechanical and management engineering. Five pre-existing departments merged in 2013, and the research results are here summarized to certify how important it was to join skills, expertise, and projects. The industrial engineering area is huge, but it is now dominated by the need to conceive and analyze new solutions, human and climate oriented to face with the actual challenges which dictate the new paradigm, which evolved from “is it feasible?” to “is it compatible with the environment and the human beings?”. There is still a lot to do, but the contents of this book demonstrate that the first steps have been done. All the researchers of the department have contributed to this book, more than 140 authors, and thus, it isthe collective outcome of the path they were able to perform all together, including administrative officers and technicians. It highlights the international relevance and multidisciplinarity of research at the university as well as the planned research lines for the next years.