The present edition offers the diplomatic transcription of MS Wellcome 542, housing a late Middle English hitherto unedited remedy-book based on the medical lore of Hippocrates, Socrates and Galen. A glossary, notes and introduction also accompany the edition. The introduction has been conceived as a state of the art of this scientific treatise, and deals with the textual transmission of the text, a codicological/palaeographic description together with the scribe's dialect and idiolect. The edition therefore conforms itself as a primary source for research not only in Historical Linguistics but also in other related fields such as the History of Medicine or Ecdotics.