The goal of this manual is to enhance the capacity of all members of the educational context, whether student, parent, teacher, administrator, or consultant, to activate the benefits of infused technologies for all learners, including those who are blind or have low vision. To accomplish this purpose this manual provides background and practical information with respect to inquiry-based education, infused technologies, and blindness and visual impairment. You will discover vignettes of real-life blind learners, tips from a blind educator, key components of accessible technology- infused education including information on adaptive technologies for applications that have not yet been designed for all learners, and practical suggestions to make online courses and Web sites accessible. For those who wish to explore further, there are numerous recommendations for further reading, organized to guide the reader to specific content.