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ADAMTS13: Biology and Disease de George M. Rodgers

ADAMTS13: Biology and Disease

Editat de George M. Rodgers
en Limba Engleză Hardback – 15 sep 2015
This comprehensive volume discusses the protease ADAMTS13, summarizing the current status of basic and clinical research. The nine authoritative chapters begin with a historical perspective followed by exploration of the biochemistry and structure-function relationships of ADAMTS13 as well as its normal function in hemostasis (cleavage of von Willebrand factor). Emerging research themes for ADAMTS13 are covered, including its potential role in angiogenesis and other aspects of cell biology. Additional topics include laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and acquired ADAMTS13 deficiency. A chapter on related thrombotic microangiopathic (TMA) disorders examines the differences between TMAs associated with ADAMTS13 deficiency and those not associated with ADAMTS13 deficiency. A final chapter reviews the preliminary information on emerging aspects of ADAMTS13, such as the status of recombinant ADAMTS13 products and their potential utility.
 
Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and Disease is a significant resource for clinical hematologists, transfusion medicine physicians, and researchers interested in hemostasis, vascular biology, biochemistry, and metalloproteases.
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Specificații

ISBN-13: 9783319087160
ISBN-10: 3319087169
Pagini: 440
Ilustrații: X, 186 p. 33 illus., 24 illus. in color.
Dimensiuni: 155 x 235 x 17 mm
Greutate: 0.53 kg
Ediția:1st ed. 2015
Editura: Springer International Publishing
Colecția Springer
Locul publicării:Cham, Switzerland

Public țintă

Research

Cuprins

1. A13: Structure and function.- 2. A13: The von Willebrand factor cleaving protease.- 3. A13: Angiogenesis and other biologic activities.- 4. A13:  Assays.- 5. Inherited A13 deficiency (Upshaw-Schulman Syndrome).- 6. Acquired A13 deficiency (TTP).- 7. Related thrombotic microangiopathies.- 8. Future directions.​

Recenzii

“The purpose is toprovide a current overview of ADAMTS13, spanning basic science and clinicalmedicine. … of interest to any medical students, residents, practicingphysicians, or allied health practitioners involved in the care of thesepatients. … If you are even remotely interested in ADAMTS13, you must get thisbook. This is most certainly one of the best current reviews of this subjectavailable today.” (Valerie L. Ng, Doody’s Book Reviews, November, 2015)

Notă biografică

Dr. George M. Rodgers received his M.D. and Ph.D. in Pharmacology from Tulane University Medical School in New Orleans, Louisiana. He completed his internal medicine training at Baylor College of Medicine in Houston, Texas, along with a hematology fellowship at the University of California, San Francisco, and served on the UCSF faculty. He is currently Professor of Medicine and Pathology at the University of Utah Medical Center in Salt Lake City and Medical Director of the Coagulation Laboratory at ARUP Laboratories. Dr. Rodgers is board certified in internal medicine, hematology and hematopathology. His clinical interests are in benign hematology, particularly coagulation disorders, and his basic research interests are in vascular biology, especially endothelial cell regulation of hemostasis. A current project is studying the role of ADAMTS13 in angiogenesis.

Textul de pe ultima copertă

This comprehensive volume discusses the protease ADAMTS13, summarizing the current status of basic and clinical research. The nine authoritative chapters begin with a historical perspective followed by exploration of the biochemistry and structure-function relationships of ADAMTS13 as well as its normal function in hemostasis (cleavage of von Willebrand factor). Emerging research themes for ADAMTS13 are covered, including its potential role in angiogenesis and other aspects of cell biology. Additional topics include laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and acquired ADAMTS13 deficiency. A chapter on related thrombotic microangiopathic (TMA) disorders examines the differences between TMAs associated with ADAMTS13 deficiency and those not associated with ADAMTS13 deficiency. A final chapter reviews the preliminary information on emerging aspects of ADAMTS13, such as the status of recombinant ADAMTS13 products and their potential utility.
 
Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and Disease is a significant resource for clinical hematologists, transfusion medicine physicians, and researchers interested in hemostasis, vascular biology, biochemistry, and metalloproteases.

Caracteristici

An up-to-date comprehensive overview of ADAMTS-13 basic science, including less-recognized aspects of the protein Covers ADAMTS-13's role in disease, including its potential as a therapeutic agent One of the only books to focus on this specific protein, it fills a gap in the literature and its coverage of both scientific and clinical aspects make it relevant both to researchers and clinicians