In Pakistan Poultry industry is facing many problems but the most serious one are diseases, particularly viral & bacterial diseases. Viral diseases are prevailing in the Country because of no specific drugs are available for their treatment. The only control measure is through vaccination. Among viral diseases Hydropericardium syndrome (HPS) was first recognized in broiler flocks in Angara Goth (Goth means small town or village) near Karachi metropolitan city of Pakistan, in late 1987. Because the disease emerged in this specific geographic area, HPS was referred to as Angara Disease or Hydropericardium Hepatitis syndrome (HHS). The syndrome was spread in the densely populated broiler growing areas all over the country within six months.