Adrenal Cortical Carcinoma is classically associated with a dismal prognosis. Yet its clinical presentation is changing (more and more classified as 'incidentaloma'). New insights have emerged on its pathophysiological mechanisms (through the genetic elucidation of familial syndromes), and Reference Centers within National and European Networks are now offering more standardised and efficient multidisciplinary clinical management of these difficult patients. All these important aspects are described by experts in nine chapters dealing with epidemiology, prognosis, and clinical management, pathology, molecular pathophysiological mechanisms, modern imaging approaches, surgical and chemotherapeutical approaches of primary and secondary lesions, and the particular aspects of adrenal cortical carcinoma in children. This book, with its many figures and photographs, will be of major interest to endocrinologists, radiologists and nuclear medicine experts, pathologists, surgeons, oncologists, paediatricians. After a thorough reading, one will better recognise a suspicious adrenal 'incidentaloma', diagnose steroid hypersecretion, suspect a familial disease, consult with the pathologist and surgeon, manipulate difficult drugs like O,p'DDD, participate in multidisciplinary discussions with oncologists, radiotherapeutists, molecular biologists... Modern medicine in action!