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Advances in Chemical Proteomics: Developments in Organic Chemistry

Editat de Xudong Yao
en Limba Engleză Paperback – 27 oct 2021
Advances in Chemical Proteomics provides essential concepts and recent applications on probes, tool compounds and concepts for chemical proteomics and then moves on to applications, including solid-phase reagents, fragment screening, designer compounds and protein lipidation. As the second volume in the Developments in Organic Chemistry series, each chapter is written by experts in the field. Users will find this to be a valuable reference for organic chemists and chemical biologists who are interested in developing tool compounds and reagents to measure and interrogate proteome, develop drug leads, and measure off-target effects and drug toxicity.
Analytical chemists who are interested in better understanding organic chemistry behind commonly used reagents for quantitative proteomics and tools compounds in the emerging field of chemical proteomics will also benefit from this comprehensive resource on the topics presented.


  • Provides an ideal, introductory book to chemical proteomics for organic chemists, pharmaceutical chemists and chemical biologists
  • Includes advanced, recent applications and reviews in chemical proteomics
  • Presents valuable work by a global team of experts from the field of proteomics
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Specificații

ISBN-13: 9780128214336
ISBN-10: 0128214333
Pagini: 268
Dimensiuni: 152 x 229 mm
Greutate: 0.36 kg
Editura: ELSEVIER SCIENCE
Seria Developments in Organic Chemistry


Cuprins

1. Tool compounds for mass spectrometry-based chemical proteomics 2. Principles of proteomic reactions of covalent inhibitors 3. Reporter tags and chemistry for probe-reacted proteins 4. Chemical derivatization of peptides for quantitative proteomics 5. Database-searching strategies for probe-reacted proteins in a proteome 6. Solid-phase reagents for discovering inhibitors of kinases 7. Fragment screening for discovering covalent probes 8. Designer compounds for locational proteomics 9. Chemical proteomics for exploring protein lipidation Targeting Author: Edward Tate 10. Synthetic evolution of indocyanine green with the 2-nitroimidazole warhead for imaging of hypoxic tumor