This book constitutes the refereed proceedings of the Second International Conference on Quantitative Ethnography, ICQE 2020, held in February 2021. Due to the COVID-19 pandemic the conference has been postponed to 2021 and was held in online format.  The 28 full papers were selected from 56 submissions. The contributions in this volume come from diverse fields and perspectives, and present the studies on advantages of using quantitative ethnography methods and techniques in a number of different domains and contexts, including ethnography and statistics, human interpretation and machine processing, etc.