During alcohol withdrawal there is a neuronal imbalance between the neurotransmitters GABA, dopamine and glutamate that trigger an increase in Reactive Oxygen Species associated with significant behavioral disorders. On the other hand, ethanol metabolism itself generates the formation of Acetaldehyde, a highly toxic metabolite capable of generating oxidative stress by different mechanisms. In the present book, the relationship between the behavioral affectations characteristic of the state of alcohol withdrawal and the presence of oxidative stress at brain level in a non-clinical model of chronic alcoholism was demonstrated. The application of medical ozone during alcohol withdrawal restores the redox balance, preserves the activity of brain mitochondrial aldehyde dehydrogenase and behavioral impairments, events associated with the quality of life of the alcoholic patient during this stage.