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Alzheimer's Disease de Philippe Derreumaux

Alzheimer's Disease: Molecular Medicine and Medicinal Chemistry, cartea 7

Editat de Philippe Derreumaux
en Limba Engleză Hardback – 30 dec 2012
Alzheimer's disease is the most common form of senile dementia, affecting more than 24 million people worldwide. This book provides a panoramic view across in vitro and in vivo studies along with computer simulations, designed to increase the readers' understanding of oligomerisation and fibril formation.
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Specificații

ISBN-13: 9781848167544
ISBN-10: 1848167547
Pagini: 464
Dimensiuni: 155 x 231 x 25 mm
Greutate: 0.84 kg
Ediția:New.
Editura: Imperial College Press
Seria Molecular Medicine and Medicinal Chemistry

Cuprins

Cellular and In Vitro Aspects of Amyloid-Beta (Aβ) Aggregation: Amyloid Hypothesis: Molecular and Cellular Aspects of Toxicity (Rakez Kayed and Cristian A Lasagna-Reeves); Models of Wild-Type and Disease-Causing Mutant β-Amyloid Fibrils. Insights from Solid-State Nuclear Magnetic Resonance Spectroscopy (Stephen C Meredith); Biophysical Characterization of Aβ Assembly (Eric Y Hayden and David B Teplow); Coordination of Metal Ions to β-Amyloid Peptide: Impact on Alzheimer's Disease (Peter Faller, Giovanni La Penna, Christelle Hureau and Sara Furlan); Amyloidogenesis, Neurogenesis, Learning, and Memory in Alzheimer's Disease: Lessons from Transgenic Mouse Models (Laure Verret and Claire Rampon); Inhibitor Design Against Cytotoxic β-Amyloid Species (Andrew J Doig); Bioinformatics and Computer Simulations of Aβ Aggregation Under Various Environmental Conditions: Kinetics of Amyloid Growth (Jessica Nasica-Labouze and Normand Mousseau); Probing the Stability of Fibril and Tubular Species Using All-Atom Molecular Dynamics Simulations in Solution: Insight into Polymorphism (Yifat Miller, Buyong Ma and Ruth Nussinov); Mechanisms of Growth of β-Amyloid Fibrils and Binding of Non-Steroidal Anti-Inflammatory Drug Ligands (Takako Takeda and Dmitri Klimov); Exploring the Structures of β-Amyloid Oligomers in Aqueous Solution Using Coarse-Grained Protein Models (Yassmine Chebaro and Philippe Derreumaux); Pathways of Amyloid Fibril Formation Using a Simplified Peptide Model (Riccardo Pellarin); From Disordered Amyloid β-Proteins to Soluble Oligomers and Protofibrils Using Discrete Molecular Dynamics (Mark Betnel, Nikolay V Dokholyan and Brigita Urbanc); Aβ Proteins - Lipid Membrane Interaction: Computational Simulation Study (Yuguang Mu); Molecular Insights into the Assembly of β-Amyloid on Surfaces and Carbon Nanotubes (Guanghong Wei, Yin Luo and Zhaoming Fu); Inhibiting Peptide and Protein Self-Aggregation: What Can Simulations Tell Us? (Joan-Emma Shea and Giorgio Colombo).