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Alzheimer's Disease: Understanding Biomarkers, Big Data, and Therapy

Autor Ahmed Moustafa
en Limba Engleză Paperback – 15 sep 2021
Nearly 44 million people have Alzheimer’s or related dementia worldwide, according to the Alzheimer’s Disease International organization. That number is expected to double every 20 years. Unlike other books on the market, Alzheimer's Disease: Understanding Biomarkers, Big Data, and Therapy covers recent advancements in cognitive, clinical, neural, and therapeutic aspects of Alzheimer’s and other forms of dementia.

First, readers are introduced to cognitive and clinical studies, focusing on the different types of memory impairment, past and future thinking. This includes the prevalence of depression, its relationship to other symptoms, and the quality of life for those with Alzheimer’s disease. In addition, the book discusses recent studies on memory dysfunction in advanced-stage Alzheimer’s disease, in comparison to early-stage, including a chapter on the underlying factors in the transition from mild cognitive impairment to Alzheimer’s diagnosis. Following this section, the book presents recent studies on the role of different cortical and subcortical structures in the development of various symptoms in Alzheimer’s disease, as well as different neural biomarkers underlying the development and treatment of the disease. In the last section of the book, therapeutic aspects of Alzheimer’s disease, focusing on behavioral and pharmacological treatments of sleep disorders, memory problems, and depression, are reviewed. The book aids readers in understanding the advances in research and care, making it a prime tool for all clinicians, psychologists, researchers, neurologists, and caregivers of dementia patients.

  • Reviews recent developments of cognitive and clinical studies
  • Covers factors underlying the transition from mild cognitive impairment to Alzheimer’s disease
  • Discusses different neural biomarkers underlying the development and treatment of Alzheimer’s disease
  • Provides a comparison of the effectiveness of various types of treatments
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Specificații

ISBN-13: 9780128213346
ISBN-10: 0128213345
Pagini: 254
Dimensiuni: 152 x 229 mm
Greutate: 0.35 kg
Editura: ELSEVIER SCIENCE

Public țintă

Advanced students and researchers in cognitive and behavioral neuroscience, psychology, psychiatry, psychotherapy, neurology

Cuprins

Part I: Mental Health in Dementia
1. Measures of depression in Alzheimer’s disease
Ahmed A. Moustafa, Wafa Jaroudi, Lily Bilson and Mohamad El Haj
2. The nature of depression in dementia: A narrative review
Ahmed A. Moustafa, Phoebe Bailey, Wafa Jaroudi, Lily Bilson and Mohamad El Haj
3. Stress and anxiety in dementia
Ahmed A. Moustafa, Shimaa Adel Heikal and Wafa Jaroudi

Part II: Advanced Topics in Dementia Research
4. Alzheimer's disease in the pupil: Pupillometry as a biomarker of cognitive processing in Alzheimer’s Disease
Ahmed A. Moustafa and Mohamad El Haj
5. Cognitive and neural correlates of vitamin D deficiency: Focus on healthy aging and Alzheimer’s Disease
Ahmed A. Moustafa, Wafa Jaroudi and Abdrabo Soliman
6. The effect of Alzheimer’s Disease on the thalamus
Ahmed A. Moustafa and Rasu Karki
7. Using big data methods to understand Alzheimer's Disease
Ahmed A. Moustafa, Samuel L. Warren and Hany Alashwal
8. Operational aspects of deep learning solutions for Alzheimer's Disease
Ahmed A. Moustafa, Dustin van der Haar and Samuel L. Warren

Part III: Treatment of Dementia
9. Treatment of depression in Alzheimer's Disease
Ahmed A. Moustafa, Lily Bilson and Wafa Jaroudi
10. Developing a vulnerability to negative affect scale for music interventions for people with dementia
Ahmed A. Moustafa, Sandra Garrido and Wafa Jaroudi
11. Using music to improve mental health in people with dementia
Ahmed A. Moustafa, Wafa Jaroudi and Sandra Garrido
12. The efficacy of Donepezil for the treatment of Alzheimer's Disease
Ahmed A. Moustafa and Samuel L. Warren

Recenzii

"...covers many topics related to Alzheimer's disease,… [including] relevant psychiatric illnesses associated with Alzheimer’s, advances in research and technological contributions, and current treatments in people with dementia…. [H]elps readers to understand how psychological research is being performed in Alzheimer's disease patients… [and] does a great job in pointing out the difficulty in performing such research as dementia studies require more longitudinal collection of data… [It] suggests possible solutions of using big database research methods to accelerate new findings in the field,… useful to readers who design research studies in Alzheimer's diseases…. [P]rovides disease pathology in relatively easy-to-understand phrases based on recent literature and discusses research models in which the disease can be studied best.… Compared to other books that talk about the specific biochemical neuropathophysiology,… [this] provides a much more general overview and psychological aspect of Alzheimer's disease." --©Doody’s Review Service, 2023, Jane Lee, MD (Northwell Health)