The presented book is concerned with the densitometric, spectrophotometric and kinetic spectrophotometric analysis of certain cephalosporin antibiotics namely; cefaclor monohydrate, cefadroxil monohydrate, cefalexin anhydrous, cefradine anhydrous, cefotaxime sodium, ceftriaxone sodium, cefoperazone sodium, cefazolin sodium, cefixime, ceftazidime pentahydrate and cefpodoxime proxetil. It comprises three main parts in addition to general introduction about cephalosporin antibiotics and a literature review includes the official and reported methods for their determination. The presented thesis has awarded the prize of the best scientific master thesis in pharmaceutical and medicinal sciences on Assiut University level.