The countdown has started. One hundred and forty meteoroids are racing toward Earth this 2112-year of the Lord. The world is still reeling from the aftereffects of World War III, having lost 60% of the human population. National and international infrastructures are weakened, and Earth is unprepared to deal with the impending apocalypse. In these desperate times, a mysterious giant blackthorn tree erupts from the steps of Saint Peter's Basilica. Many see it as a sign of hope from heaven, and the faithful fill Saint Peter's Square, further taxing the Vatican's limited resources. A cardinal, religious sister, and young priest team up with Nephilim vampire Cain'el, an outcast prince of Eden, in their quest for religious artifacts with magical powers. Their most deadly foe is an Asian underground crime leader known as Dragona'ra, a powerful vampire princess of Eden who deeply resents the Holy See's efforts to rebuild the Church in China. Meanwhile, a powerful vampire Cardinal and his insane dwarf companion haunt the Vatican, preying on those who won't be missed. A fight that began 25,000 years ago reaches its climax as Cain'el confronts the undead vampire prince Ab'el of Eden in a final battle. Angels and Vampires was inspired by Eugene Sue's classical 19th century epic fantasy, The Wandering Jew."