Animal Models in Radiotracer Design
Editat de Richard M. Lambrecht, William C. Eckelmanen Limba Engleză Paperback – 13 oct 2011
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Specificații
ISBN-13: 9781461255987
ISBN-10: 1461255988
Pagini: 252
Ilustrații: XIV, 234 p.
Dimensiuni: 155 x 235 x 13 mm
Greutate: 0.36 kg
Ediția:Softcover reprint of the original 1st ed. 1983
Editura: Springer
Colecția Springer
Locul publicării:New York, NY, United States
ISBN-10: 1461255988
Pagini: 252
Ilustrații: XIV, 234 p.
Dimensiuni: 155 x 235 x 13 mm
Greutate: 0.36 kg
Ediția:Softcover reprint of the original 1st ed. 1983
Editura: Springer
Colecția Springer
Locul publicării:New York, NY, United States
Public țintă
ResearchCuprins
1 Animal Models in Biomedical Research and Radiotracer Design.- Brief Survey of Chapters.- Guidelines for Research with Animals.- References.- 2 The Development of Radiotracers that are Substrates FOR (Catecholamine) Uptake1 and Uptake2.- Introduction: Development of Informational Drugs.- Catecholamine Uptake1 and Uptake2.- Compounds Other Than Catecholamines that Participate in Uptake1 and Uptake2.- Species Differences.- The Special Case of the Adrenal Medulla.- Other Extraneuronal Uptake.- Possible Pathological Role of Changes in Uptake1.- Possible Future Directions of Research.- Summary.- References.- 3 Monoclonal Antibodies: the Design of Appropriate Carrier and Evaluation Systems.- Monoclonal Antibody Applications.- Requirements for the Receptor Antigen.- Requirements for the Carrier Antibody.- Tumor Model Systems.- Summary.- References.- 4 Small Animal Oncological Models for Screening Diagnostic Radiotracers.- The Need for Animal Tumor Models.- Cancer.- Classification of Neoplasms.- Growth and Spread of Neoplasms.- Animal Tumor Models.- Selection of Animal Tumor Models Based on Mechanism of Uptake of the Radiotracer.- Animal Tumor Models in the Literature of Radiotracers and Radiopharmaceuticals.- References.- 5 111In-Labeled Platelets for the Detection of Vascular Disorders in Animal Models.- Acute Arterial Lesion Model.- Atherosclerosis.- Coronary Artery Thrombosis.- Vascular Grafts.- References.- 6 Animal Models in the Study of Hepatobiliary Radiotracers.- and Characteristics of Hepatobiliary Agents.- Species and Hepatobiliary Excretion.- Laboratory Animal Technique Considerations.- Summary.- References.- 7 Experimental Models and Evaluation of Animal Data for Renal Radiodiagnostic Agents.- Evaluation of Animal Biodistribution Data.- Comparison of Biodistribution of Renal Agents in Different Species.- Choice of Animal Models.- Models of Human Renal Diseases in the Rat.- Conclusions.- References.