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Anti-Obesity Drug Development: Physiology, Pharmacology and Drug Delivery

Editat de Fadia Salah Youssef, Mohamed Lotfy Ashour
en Limba Engleză Paperback – mai 2025
Anti-Obesity Drug Development: Physiology, Pharmacology and Drug Delivery is a complete reference for pharmaceutical researchers in this key area of research and clinical development. The contents of the book are organized in four parts. The first provides an overview of the foundations and historical development of anti-obesity drugs, including extensive discussion of comorbidities and how they impact drug activity and efficacy. Part two is dedicated to the drug targets involved in the progression of obesity treatment. These include GLPRI and GIPR agonists, Incretin/Glucagon, RM-493 and Liraglutide, Pramlintide and metreleptin, Growth Hormone, FXR and GPR131, and the Gut Microbiota. Part three discusses the most common drugs available in the market and their pharmacological parameters. The final part of the book covers all natural products known to have scientific evidence on the treatment of obesity. Anti-Obesity Drug Development: Physiology, Pharmacology and Drug Delivery is the perfect reference for pharmacology researchers and those involved in new drug development both in academic and corporate environments. Research-physicians, endocrinologists, and nutritionists will also benefit from the comprehensive overview of treatments covered in this book.

  • Provides researchers who seek information to start their future studies with conclusions from current research projects
  • Covers natural phytochemicals as alternative to synthetic drugs in the treatment of obesity
  • Includes comprehensive information about adverse effects, contraindications, therapeutic doses as well as toxicity of obesity treatment drugs
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Specificații

ISBN-13: 9780443289002
ISBN-10: 044328900X
Pagini: 500
Dimensiuni: 216 x 276 mm
Editura: ELSEVIER SCIENCE

Cuprins

Part I – Foundations and historical development on Anti-Obesity Drugs
1. Introduction
2. Historical overview of drug development and therapeutics
3. Neuroendocrine consideration
4. Alternative therapies
5. Comorbidities and their impact on therapies
6. Challenges for anti-obesity drug development FDA approved versus non-conventional and non-drug therapy of obesity

Part II – Drug targets involved in progression and treatment of obesity
7. GLP1R and GIPR agonists
8. Incretin/Glucagon
9. RM-493 and Liraglutide
10. Pramlintide and metreleptin
11. Growth hormone
12. Farnesoid X receptor (FXR) and membrane bound bile acid receptor (GPR131)
13. Gut Microbiota Matrix metalloproteinase (MMPs) Drug delivery technologies

Part III - Drugs
14. Orlistat
15. Liraglutide
16. Lorcaserin
17. Semaglutide
18. Setmelanotide
19. Tirzepatide
20. Combination Therapies:
a. phentermine/topiramate
b. naltrexone/bupropion

Part IV – Natural Products
21. Chitosan
22. Chromium Picolinate
23. Conjugated Linoleic Acid (CLA)
24. Glucomannan
25. Green Tea Extract
26. Green Coffee Extract
27. Guar Gum
28. Hoodia
29. 7-Keto-DHEA
30. Ephedra
31. Bitter Orange