Antibacterial Drugs Today de A. P. Ball

Antibacterial Drugs Today

A. P. Ball

J.A. Gray

J.McC. Murdoch

en Limba Engleză Paperback – 31 mai 1979

Since the first edition there has been a great demand for this book. It has been revised to include up-to-date and new entries covering recent additions to the availa ble drugs. As well there are now sections on clinical situations, or types of patient, presenting especial problems. The authors hope this new material will enhance the effectiveness of the book as a guide to this rapidly advancing and changing therapeutic situation. A.P.B. J.A.G. J.McC.M. July, 1978 v Contents I. Antibacterial Drugs 1.1 Mechanisms of Action I .2 Side Effects and Toxicity 2 2. The Sulphonamides .............................. . 2 2.1 Antibacterial Activity .... 2 2.2 Mode of Antibacterial Action 2.3 Pharmacology 3 2.4 Therapeutic Indications ... 4 2.5 Dosage ....................... . 4 2.5.1 Short Acting Sulphonamides ..................... . 4 2.5.2 Long Acting Sulphonamides 5 2.5.3 Non-absorbable Sulphonamides 5 2.6 Side Effects and Toxicity 5 2.6.1 Nephrotoxicity ............................... . 5 2.6.2 Haematological Abnormalities 5 2.6.3 Pulmonary Disease .. . 5 2.6.4 Hypersensitivity .................................................. . 6 2.7 Drug Interactions ... 6 3. The Natural Penicillins - Benzylpenicillin (Penicillin G) and Phenoxymetbylpe- cillin (Penicillin V) .......................... . ..................... .

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Cuprins

1. Antibacterial Drugs.- 1.1 Mechanisms of Action.- 1.2 Side Effects and Toxicity.- 2. The Sulphonamides.- 2.1 Antibacterial Activity.- 2.2 Mode of Antibacterial Action.- 2.3 Pharmacology.- 2.4 Therapeutic Indications.- 2.5 Dosage.- 2.6 Side Effects and Toxicity.- 2.7 Drug Interactions.- 3. The Natural Penicillins — Benzylpenicillin (Penicillin G) and Phenoxymethylpenicillin (Penicillin V).- 3.1 Physicochemical Properties.- 3.2 Mode of Antibacterial Action.- 3.3 Antibacterial Activity.- 3.4 Pharmacology.- 3.5 Therapeutic Indications.- 3.6 Dosage.- 3.7 Side Effects and Toxicity.- 4. The Semi-synthetic Penicillins.- 4.1 Phenoxypenicillins.- 4.2 Penicillinase Resistant Penicillins.- 4.3 Other Penicillinase Resistant Penicillins.- 4.4 Broad Spectrum Penicillins.- 5. Mecillinam and Pivmecillinam.- 5.1 Antibacterial Activity.- 5.2 Mode of Action.- 5.3 Pharmacology.- 5.4 Indications.- 5.5. Dosage.- 5.6 Side Effects.- 6. Co-trimoxazole (Trimethoprim-sulphamethoxazole).- 6.1 Antibacterial Activity.- 6.2 Mode of Action.- 6.3 Pharmacology.- 6.4 Indications.- 6.5 Dosage.- 6.6 Contraindications.- 6.7 Side Effects and Toxicity.- 6.8 Drug Interactions.- 7. Chloramphenicol.- 7.1 Therapeutic Indications.- 8. The Tetracyclines.- 8.1 Antibacterial Activity.- 8.2 Pharmacology.- 8.3 Therapeutic Indications.- 8.4 Side Effects and Toxicity.- 9. The Macrolides.- 9.1 Erythromycin.- 9.2 Spiramycin and Triacetyloleandomycin.- 10. Lincomycin and Clindamycin.- 10.1 Mode of Action.- 10.2 Antibacterial Activity.- 10.3 Pharmacology.- 10.4 Therapeutic Indications.- 10.5 Dosage.- 10.6 Side Effects and Toxicity.- 11. Fusidic Acid (Sodium Fusidate).- 11.1 Mode of Action.- 11.2 Antibacterial Activity.- 11.3 Pharmacology.- 11.4 Therapeutic Indications.- 11.5 Dosage.- 11.6 Side Effects and Toxicity.- 12.The Urinary Antiseptics.- 12.1 Nitrofurantoin.- 12.2 Nalidixic Acid.- 12.3 Oxolinic Acid.- 13. Cephalosporins.- 13.1 Cephaloridine.- 13.2 Cephalothin.- 13.3 Cephalexin.- 13.4 Cephradine.- 13.5 The Cephamycins.- 13.6 Newer Cephalosporin Derivatives.- 14. Peptide Antibiotics (Polymyxin B and Polymyxin E).- 14.1 Antibacterial Activity.- 14.2 Pharmacology.- 14.3 Therapeutic Indications and Dosage.- 14.4 Side Effects and Toxicity.- 15. The Aminoglycosides.- 15.1 Streptomycin.- 15.2 Kanamycin.- 15.3 Gentamicin.- 15.4 Tobramycin.- 15.5 Neomycin, Framycetin and Paromomycin.- 15.6 Newer Aminoglycosides.- 16. Metronidazole.- 16.1 Antibacterial Activity.- 16.2 Mode of Action.- 16.3 Pharmacology.- 16.4 Therapeutic Indications $.- 16.5 Dosage.- 16.6 Toxicity and Interactions.- 17. Antituberculosis Drugs.- 17.1 Isoniazid.- 17.2 Rifampicin.- 17.3 Ethambutol.- 17.4 Streptomycin.- 17.5 Para-aminosalicylic Acid (PAS).- 17.6 Capreomycin.- 17.7 Other Drugs.- 18. Chemotherapy of Gram-negative Bacillary Infections.- 18.1 General Considerations.- 18.2 Organisms.- 18.3 Choice of Antibacterial Agents.- 18.4 Routes of Administration and Duration of Therapy.- 18.5 Precautions.- 18.6 Specific Infections.- 19. Anaerobic Infections.- 19.1 Clostridial Infections.- 19.2 Non-clostridial Anaerobic Infections.- 20. Antibacterial Therapy in Renal and Hepatic Disease.- 20.1 Renal Disease.- 20.2 Hepatic Disease.- 21. Antibacterial Therapy in Infants and Children.- 21.1 General Considerations.- 21.2 Dosage.- 21.3 Clinical Pharmacology in Premature Infants and the Newborn.- 21.4 Special Considerations with Individual Drugs.- 21.5 Specific Infections in Infants.- 22. Antibacterial Therapy in the Elderly.- 22.1 General Principles.- 22.2 Urinary Tract Infection.- 22.3 Chest Infection.- 22.4 Skin and Soft TissueInfection.- 23. Antibacterial Drugs in Obstetrics and Gynaecology.- 23.1 Obstetrics.- 23.2 Gynaecology.- 24. Surgical Infections.- 24.1 Prophylaxis of Surgical Infection.- 24.2 Pyrexia Following Surgery.- 25. Opportunistic Infection.- 25.1 Exogenous Opportunistic Infection.- 25.2 Endogenous Opportunistic Infection.- 25.3 Bacteraemia.- 25.4 Management of Opportunistic Infection.- 26. The Management of Tuberculosis.- References.