The consumption of Avocado fruit is not toxic to the system and is hepatoprotective. The presence of biologically active ingredients such as alkaloids, flavonoids, triterpenoids, minerals and vitamins, readily accounts for antihyperglycemic, antidiabetic dyslipidemic, hypolipidemic and anti-oxidative properties of P.americana fruit. The observed properties of avocado fruit extract may be attributed to the normalization of glucose metabolism, inhibition of lipolysis in addition to its potential FRSA. The extracts from leaf of P.americana by dichloromethane or methanol and extracts from fruit by dichloromethane or methanol possessed hypolipidemic activity in tyloxapol-induced hyperlipidemia in rats. Thus, these extracts may be useful in lowering cholesterol and triglyceride levels in hyperlipidemia. Our results also concluded that the fraction and sub-fraction of the fruit of Avocado tested for antidiabetic activity have shown appreciable results in ameliorate the blood glucose level and related other complications. Hence these findings also may open the door for a new, alternative, leading drug for treating diabetic patients in future.