Cyanobacterial secondary metabolites have diverse antagonistic activity that lead to disintegration of algal, bacterial and fungal growth. This work majorly focuses on the ability of cyanobacteria to be used as an antifungal agent, since a long time the antifungal drugs are chemical based, they are not only having problems of being hazardous when overused but also has led to the increase in the resistant power of many disease causing fungi. Cyanobacteria have a potential to become the leading antimicrobial drug as it has various advantages over the conventional chemical drugs. However, intensive research required to channelize the overall potential of cyanobacteria to be used as an antifungal drug to combat different diseases caused by fungi.