In recent years, the design and construction of polymeric metal complexes have attracted increasing attention. Hence, we have carried out the synthesis and characterization of various ligands and its coordination polymers derived from 8-hydroxyquinoline and 2,2'-(phenyl azanediyl) diethanol derivatives, we have carried out biological activity of all synthesized compounds. The aim of this book is to provide a brief knowledge about the microbial activity of ligands and their coordination polymers. This study was carried out Dr. Khyati D. Patel at Chemistry Department, Sardar Patel University, Vallabh Vidyanagar (Gujarat). Authors express their sincere gratitude to the authorities of Department of Chemistry, Sardar Patel University. We hope the readers can enjoy this text and find it useful in their respective studies.