Antimicrobial Peptides: A Roadmap for Accelerating Discovery and Development
Editat de Luis H. Reyes, Juan C. Cruz, Gregory R. Wiedmanen Limba Engleză Paperback – 3 dec 2024
- Covers computational tools (including emerging artificial intelligence algorithms) and microfluidic systems for discovery and high-throughput screening of AMPs
- Discusses the application of bioprocess engineering scale-up approaches for AMPs' production and purification with the aid of process simulation tools and rapid prototyping
- Highlights user-centered design and formulation of products with AMPs
- Describes the whole pipeline for AMPs production
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Specificații
ISBN-13: 9780443153938
ISBN-10: 0443153930
Pagini: 438
Dimensiuni: 216 x 276 mm
Greutate: 0.45 kg
Editura: ELSEVIER SCIENCE
ISBN-10: 0443153930
Pagini: 438
Dimensiuni: 216 x 276 mm
Greutate: 0.45 kg
Editura: ELSEVIER SCIENCE
Cuprins
Introduction. Antimicrobial peptides: from the bench to the bedside Section 1. Computational approaches 1. Bioinformatic methods for the design of antimicrobial peptides 2. Fundamentals of molecular dynamics for antimicrobial peptides' discovery 3. Artificial intelligence for the discovery of antimicrobial peptides 4. Computational tools for handling large databases of biological relevance 5. Statistical analysis and data interpretation Section 2. Experimental approaches 6. Chemical synthesis of peptides: conventional and novel routes 7. Physicochemical and biochemical characterization 8. Non-rational approaches based on microbial surface display 9. Classical and emerging approximations for the screening of peptide libraries 10. Scaling-up of biological production processes 11. Downstream processing 12. Physicochemical and biochemical characterization Section 3. Translational studies 13. Biological characterization: in vitro and in vivo studies 14. Pre-clinical and clinical studies 15. Formulation and product design 16. Packaging, long-term stability, and usability 17. Quality control and assurance