Even as its young men went off to fight in the Great War, there were opportunities for a fresh start on Philadelphia's streets. Into this bustling town came Pauline Bright and her husband, filled with hope that they could now give their three daughters a chance at a better life. But just months after they arrive, the Spanish Flu reaches the shores of America. As the pandemic claims more than twelve thousand victims in their adopted city, they find their lives left with a world that looks nothing like the one they knew. But even as they lose loved ones, they take in a baby orphaned by the disease who becomes their single source of hope.