In this study, we examined four randomly selected copper-bearing minerals-azurite, malachite, bornite, and chalcopyrite. Our objectives were to examine and enumerate the crystalline and chemical properties of each of the minerals; to determine which, if any, of the Cu-bearing minerals might adversely affect systems biota; and to provide a multi-procedure reference. Our laboratory work included use of computational software for quantifying crystalline and amorphous material and optical and electron imaging instruments to model and project crystalline structures. We also conducted chemical weathering, human fluid, and enzyme simulation studies.