Mythology has always populated the various forms of human expression, especially in the artistic field (literature, theatre, music, painting). With the technological increment, new languages also began to serve as a herald for various myths that, updated, were reinserted in current social, political, economic and cultural contexts, allowing new ways of thinking about human existence, according to the values of each time. This is what happened in the film What's up, my brother, where are you? released in 2000 as a comedy, written and directed by the filmmaker brothers Joel and Ethan Coen. The production, as the authors explicitly propose, is a proposed re-reading of the mythical Ulysses for the beginning of the 1930s in the United States. From the epic a comedy was born, presented as an audiovisual work. Thus, we analyse the relationship between Homer's epic Odyssey and the film E ai meu irmão, cadê você? bringing to light aspects that intertwine in a comparative line, from the point of view of the Coen brothers' rereading.