Azapropazone: 20 years of clinical use

Section I Experimental.- 1 Introduction to therapy with azapropazone.- 2 The chemical classification of azapropazone.- 3 Survey of toxicological investigations of azapropazone.- 4 The mode of action of azapropazone in relation to its therapeutic actions in rheumatic conditions and its major side-effects.- 5 Pharmacokinetic properties of azapropazone in comparison to other NSAIDs.- 6 The pharmacokinetics of azapropazone.- 7 Mathematical model for assessing risk of gastrointestinal reactions to NSAIDs.- 8 Reduction of irreversible injury in animal models of myocardial ischaemia by treatment with azapropazone.- 9 Dual inhibitory effects of azapropazone on both neutrophil migration and function: relation to cardiovascular function.- 10 Aspects of clinical pharmacology and bioavailability of azapropazone.- 11 Immunochemical studies on azapropazone.- Section II Therapeutic Actions.- 12 Untersuchungen zur Arthrose [Studies in osteoarthritis].- 13 Studies on gout and urate elimination by azapropazone.- 14 Die Analgetische Wirksamkeit von Azapropazon [Analgesic effects of azapropazone].- 15 Überblick über die Anwendung von Azapropazon nach operativen Eingriffen und bei traumatisierten Patienten [Review of application of azapropazone in post-operative and traumatic conditions].- 16 Clinical trial methodology in rheumatoid arthritis: azapropazone studies.- 17 Comparative effects of azapropazone on the progression of joint pathology on osteoarthritis.- 18 Serious gastrointestinal reactions to azapropazone: an estimate of the risk.- 19 Tolerance of azapropazone: allergic and pseudo-allergic reactions and comparison with other NSAIDs.- 20 Haematological reactions.- 21 Epilogue, with some thoughts for research on azapropazone.