An attack on the John Hancock Observatory rocks Kerry O'Malley's first day as Special Agent In Charge of the Chicago FBI Field Office. After communications fail, her new team realizes that Corbin Setag, the wealthy Choice tech mogul responsible for multiple kidnappings and experimentation on humans, has returned to complete his agenda. Determined that her family will not be a target this time, Kerry puts the house on lock-down. The FBI and CSI teams discover that Setag may only be a player in a much larger plot. A Russian crime organization, an international gang, and a small coalition of religious terrorists have traded technology and money with Setag, but the investigators struggle to determine why. Additionally, Kerry's brother Neil, an agent with the EU Navy's Special Forces, enters a potentially deadly situation. After his disappearance, a mysterious group approaches Kerry with a plan to rescue Neil and take down Corbin Setag and his sentient computer, 289. As Kerry embarks on her first mission for this Group, she realizes the implications of their extensive influence as she discovers their members in nearly every facet of her life.