Behavioral Teratogenesis and Behavioral Mutagenesis: A Primer in Abnormal Development
Autor E.L. Abelen Limba Engleză Paperback – 6 feb 2012
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Specificații
ISBN-13: 9781461280569
ISBN-10: 1461280567
Pagini: 256
Ilustrații: 254 p.
Dimensiuni: 170 x 244 x 13 mm
Greutate: 0.41 kg
Ediția:Softcover reprint of the original 1st ed. 1989
Editura: Springer Us
Colecția Springer
Locul publicării:New York, NY, United States
ISBN-10: 1461280567
Pagini: 256
Ilustrații: 254 p.
Dimensiuni: 170 x 244 x 13 mm
Greutate: 0.41 kg
Ediția:Softcover reprint of the original 1st ed. 1989
Editura: Springer Us
Colecția Springer
Locul publicării:New York, NY, United States
Public țintă
ResearchCuprins
1. In the Beginning Was the Word and the Word Was … DNA.- The Living Cell.- Mendel’s Model.- Chromosome Theory.- The Cell Cycle.- Mitosis.- Meiosis.- Gametogenesis.- Sperm Imprinting.- Genetic Variability.- Gene Theory.- The Double Helix.- How DNA Sends Messages.- You Are a Degenerate.- Junk Genes?.- What Turns You On?.- Pleiotropy.- Epistasis.- The Molecular Clock.- Finding Eve.- The Origin of Species.- Genetic Engineering.- References.- 2. Behavior Genetics.- The Heritability of Behavior.- Paradigms Used in Human Behavioral Genetics Research.- Schizophrenia.- Alzheimer Disease.- Alcoholism.- Phenylketonuria.- Fragile X.- Intelligence.- A Flutist Needs a Flute to Be a Flutist.- Prenatal Learning in the Classwomb.- References.- 3. Some DNA Is Born Great, Some Never Achieves Its Greatness, and Some Has Its Greatness Poisoned before It Can Be Recognized.- Sources of Mutations: Spontaneous versus Induced.- Types of Mutations.- Somatic versus Gametic Mutations.- Categories of Mutations.- Conditional Mutations.- Point Mutation.- Death by Beans.- Sister Chromatid Exchange.- Chromosomal Mutations.- Down Syndrome.- Sex Chromosome Anomalies.- Genome Mutations.- Agents Causing Mutations.- Ultraviolet Radiation.- Chemical Causes of Mutation.- Some Laboratory Tests for Mutagens.- DNA Repair Mechanisms.- Appendix A. Prenatal Testing.- References.- 4. From Gene to Brain.- Preimplantation.- Implantation.- Gastrulation.- Induction.- Critical Period.- The Beginning of a Brain.- Proliferation.- Cell Migration.- Pattern Formation.- Differentiation.- Relationship of Animal Brain Development to Human Brain Development.- The Neuron.- The Nerve Impulse.- Synaptogenesis.- Neurotransmitters as Inducers.- Long-Range Induction.- Glia and Myelination.- Modification of Synaptic Connections.-Appendix A. Malformations of CNS Development Due to Failure of Neuropore Closure.- Appendix B. Basic Functional Neuroanatomy.- Appendix C. Research Techniques in Neuroanatomy and Neurophysiology.- References.- Chapters 5. Behavioral Teratogenesis.- Behavioral Teratology.- Principles of Teratology.- Appendix A. Routes of Administration.- References.- 6. Identifying Human Behavioral Teratogens: Designs and Methods.- Definition of Birth Defects.- Ascertainment.- Population Being Evaluated.- Procedures for Identifying Teratogens.- Descriptive Studies.- Analytical Evaluations.- Apgar Test.- Prechtl Exam.- The Brazelton Test.- Scanlon.- Bayley Scales.- Visual Recognition Memory.- Reaction Time.- Intelligence Tests.- Summary and Conclusions.- Appendix A. Diagnostic Criteria for Attention Deficit Disorder with Hyperactivity.- References.- 7. Testing Animal Behavioral Teratogens: Designs and Methods.- Rationale for Studies in Animals.- Methodological Issues.- Test Methods.- Developmental Landmarks.- Learning/Memory Tasks.- Active Avoidance.- Passive Avoidance.- Maze Learning.- Spontaneous Alteration.- Reversal Learning.- Activity.- Observational Techniques.- Rotorod.- Preference Tests.- Sexual Behavior in the Rat.- Acoustic Startle.- Seizure Susceptibility.- Operant Behavior.- Sensitivity to Drugs.- References.- 8. Regulatory Protocols for Identifying Teratogens.- FDA Guidelines.- Behavioral Teratology Testing in Japan.- Behavioral Teratology Testing in the United Kingdom.- Behavioral Teratology Testing in France and Italy.- Efforts to Create a Behavioral Teratology Test Battery in the United States.- Summary and Conclusions.- References.