This document is part of a two-volume set prepared under the Federal Transit Administration's (FTA) General Technical Assistance Program, to provide guidance to the recipients of FTA funding that are required to test their safety-sensitive employees for drug use and alcohol misuse. This volume discusses "best practices" used by employers to establish and maintain a compliant testing program. The other volume, Implementation Guidelines for Drug and Alcohol Regulations in Mass Transit, explains the regulatory requirements, which were revised in 2001.