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Bioactive Compounds from Natural Sources: Natural Products as Lead Compounds in Drug Discovery de Corrado Tringali

Bioactive Compounds from Natural Sources: Natural Products as Lead Compounds in Drug Discovery

Editat de Corrado Tringali
en Limba Engleză Hardback – 27 sep 2011
The first edition of Bioactive Compounds from Natural Sources was published in a period of renewed attention to biologically active compounds of natural origin. This trend has continued and intensified—natural products are again under the spotlight, in particular for their possible pharmacological applications. Largely focusing on natural products as lead compounds in drug discovery, Bioactive Compounds from Natural Sources, Second Edition: Natural Products as Lead Compounds in Drug Discovery is actually a completely new volume containing surveys of selected recent advances in an interdisciplinary area covering chemistry of natural products, medicinal chemistry, biochemistry, and other related topics.
Written by some of the most reputed scientists in the field, this second edition includes new chapters from authors who contributed to the first edition as well as many chapters compiled by new authors. Introducing the reader to strategies and methods in the search for bioactive natural products, this book covers topics including:
  • Natural sources of bioactive compounds such as aquatic cyanobacteria, filamentous fungi, and tropical plants,
  • The tremendous potentiality of metabolic engineering of natural products biosynthesis
  • The contribution of emerging or developing technologies to the study of bioactive natural compounds, namely computational methods and circular dichroism
  • The potential of natural or natural-derived compounds for specific therapeutic applications: treatment of viral diseases, regulation of hypoxia-inducible factor, antimalarials, modulation of angiogenesis, and antitumor and wound-healing activity
  • Selected examples of natural product families and related synthetic analogues, namely polyphenols and campthotecins
Compiled for researchers and Ph.D. students working in interdisciplinary fields, this book will also be appreciated by readers without a background in chemistry interested in bioactive natural products, their biological and pharmacological properties, and their possible use as chemopreventive or chemotherapeutic agents. Conversely, the biological and pharmacological data and methods are accessible by chemists.
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Specificații

ISBN-13: 9781439822296
ISBN-10: 1439822298
Pagini: 648
Ilustrații: 278 b/w images, 28 color images, 29 tables and less than 100
Dimensiuni: 156 x 234 x 35 mm
Greutate: 1.08 kg
Ediția:Revizuită
Editura: CRC Press
Colecția CRC Press
Locul publicării:Boca Raton, United States

Public țintă

Professional

Cuprins

Strategies and Methods for a Sustainable Search for Bioactive Compounds. Discovery of Potential Anticancer Agents from Aquatic Cyanobacteria, Filamentous Fungi, and Tropical Plants. Metabolic Engineering of Natural Product Biosynthesis. Computational Approaches for the Discovery of Natural Lead Structures. Recent Advances in the Application of Electronic Circular Dichroism for Studies of Bioactive Natural Products. Natural Products as Treatments for and Leads to Active Compounds in Viral Diseases. Natural Products as Inhibitors of Hypoxia-Inducible Factor-1 (HIF-1). From Antitumor or Wound Healing Actions of Natural Products through Angiogenesis. From Natural Polyphenols to Synthetic Antitumor Agents. Resveratrol against Major Pathologies: From Diet Prevention to Possible Alternative Chemotherapies with New Structural Analogues. Drug Discovery from Natural Substances—A Case Study: Camptothecins. Plant Compounds and Derivatives as Inhibitors of Cancer Cell Multidrug Resistance. Recent Advances in the Search of Novel Calmodulin Inhibitors from Selected Mexican Plants and Fungi. Neuroprotective Effects of Natural Products from Traditional Chinese Herbs. Drugs for the Neglected Disease Malaria based on Natural Products. Endophytic Microorganisms as a Source of Bioactive Compounds. Biologically Active Natural Products from Australian Marine Organisms.

Notă biografică

Professor Corrado Tringali obtained his BA in chemistry at the University of Catania, Italy, in 1973. From 1977 to 1985 he was an assistant professor, teaching courses in organic chemistry and physical methods in organic chemistry. In November 1985 he became an associate professor (organic chemistry), and since November 2001 he has been a full professor (teaching courses in organic chemistry, natural products chemistry, and physical methods in organic chemistry). At present, he is coordinator of the international Doctorate of Research in Chemical Science program at the University of Catania (Cycles XXII –XIV).

Recenzii

Praise for the Previous Edition
"…The title of the book gives a good description of the chapters, which are very detailed and interesting in their multi-disciplinary content of biology, biochemistry and chemistry. Since Professor Tringali is the editor, it is not surprising that the chapters tend to include useful details of NMR data. All of the chapters have a good literature reference list. This book is recommended to all natural products researchers."
—Robert J. Nash, Institute of Grassland and Environmental Research, in Phytochemistry
"The book is well indexed with a detailed subject index and a separate natural source index listing the genus and species of each sample described in the text. References are through 1998, and in general the book is well organized with the format being consistent throughout the volume, making it easy to read. This book is certain to be of interest to those individuals new to the field of natural products as well as to senior scientists interested in a review of the subject areas covered by chapter."
—Mark T. Hamann, The University of Mississippi, in Journal of Natural Products Review
"… All in all, the book, including the excellent references, provides a good introduction to the methods and classes of natural products. It is an excellent starting point for new graduate students, and a useful reference for practitioners in the natural products field."
—W. Ayer, University of Alberta, Royal Society of Chemistry

Descriere

This book focuses on the modern approach to the isolation of biologically active natural products and provides numerous examples of the isolation and characterization of secondary metabolites. It emphasizes the synthetic or semi-synthetic analogues of natural products, relevant to those working on biomedical applications of natural products. It includes chapters on general methods together with more specific chapters discussing the main topics in the field, including important families or properties of bioactive natural products, synthesis of analogues, biological evaluation of both natural and synthetic products, and structure-activity relationship studies.