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Bioactive Natural Products: Detection, Isolation, and Structural Determination, Second Edition

Editat de Steven M. Colegate, Russell J. Molyneux
en Limba Engleză Hardback – 14 dec 2007
Following the successful format of the original, this new edition presents applications of the most recent techniques for the detection, isolation, and structural determination of bioactive natural products. It features new case studies and illustrations that demonstrate applications of techniques covered in the book. Complementing as much as replacing the first edition, most of the contributors are new. The text includes updates on chemical extraction, and NMR-based structure determination, and new contributions on liquid chromatography linked with mass and NMR spectroscopy, dereplication approaches, assessment of source material for natural products and novel bioassay development.
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Specificații

ISBN-13: 9780849372582
ISBN-10: 0849372585
Pagini: 620
Ilustrații: 1 Halftones, black and white; 16 Tables, black and white; 314 Illustrations, black and white
Dimensiuni: 178 x 254 x 41 mm
Greutate: 1.56 kg
Ediția:Revizuită
Editura: CRC Press
Colecția CRC Press
Locul publicării:Boca Raton, United States

Public țintă

Professional

Cuprins

Introduction and Overview. Detection and Isolation of Bioactive Natural Products. Nuclear Magnetic Resonance Spectroscopy: Strategies for Structure Determination. Quantitative NMR of Bioactive Natural Products. Development and Application of LC-NMR Techniques to the Identification of Bioactive Natural Products. Determination of the Absolute Configuration of Bioactive Natural Products using Exciton Chirality Circular Dichroism. Separation of Enantiomeric Mixtures of Alkaloids and their Biological Evaluation. UV Dereplication of Natural Products Extracts. Liquid Chromatography-Mass Spectrometry in Natural Product Research. Application of High-Speed Counter-Current Chromatography to the Isolation of Bioactive Natural Products. Biosensing Approach in Natural Products Research. Anticancer Drug Discovery and Development from Natural Products. Sourcing Natural Products from Endophytic Microbes. Isolation of Bioactive Natural Products from Myxobacteria. Naturally-occurring Glycosidase Inhibitors. Bioassay-Directed Isolation and Identification of Anti-aflatoxigenic Constituents of Walnuts. Bioactive Peptides in Hen Eggs. Biological Fingerprinting Analysis: Strategy For Screening of Bioactive Compounds in Traditional Chinese Medicines. Antimalarial Compounds from Traditionally-used Medicinal Plants. Germination Stimulant in Smoke:  Isolation and Identification. Plant-associated Toxins: Bioactivity-guided Isolation, Elisa and LCMS Detection.

Recenzii

"Overall, Bioactive Natural Products, 2nd edition is a book that can be read from cover to cover for both benefit and pleasure. Thus. I highly recommend this book for active natural products scientists, not only for its quality and timeliness but also for its projection of the multidisciplinary nature of natural products research."
--Ehab A. Abourashed, Chicago State University
"Overall, Bioactive Natural Products, 2nd edition is a book that can be read from cover to cover for both benefit and pleasure. Thus. I highly recommend this book for active natural products scientists, not only for its quality and timeliness but also for its projection of the multidisciplinary nature of natural products research. "
--Ehab A. Abourashed, Chicago State University
"This is a hefty book; not that this is a criticism. With 605 pages of relatively small print the volume contains a wealth of information...Photographs, chemical structures, schemes, flow diagrams, graphs, chromatographic spectra, formulae both mathematical and chemical, and compendial tables add to this epic work...it is certainly worthy of a place on the bookshelf, if not open (health and safety issues here?) on the laboratory bench."
--Steve Mitchell, Faculty of Medicine, Imperial College London
"As evidenced by their publishing histories, these new contributors were chosen because of their familiarity with their topics and their personal research in the areas addressed. … should in the library of every department that is involved in natural product research. Everyone who has the first edition will value this second edition equally, if not more so, as its complementary extension."
– Robert J. Krueger, Department of Pharmaceutical Sciences, Ferris State University, Michigan in Journal of Medicinal Chemistry, Vol. 51, No. 12, 2008
"The editors did a fine job of organizing the chapters into a cohesive book . . . The main strength of the book is the combination of real-world examples. This enables natural products chemists to apply their principles outlined in the book to their own specific application . . . would be an invaluable resource for those researchers involved with natural product chemistry, and it would also be very useful for those analytical chemists involved in the characterization of botanicals."
– Mark C. Roman, President, Tampa Bay Analytical Research, Inc., in HerbalGram, Nov 2008- Jan 2009, No. 80

Notă biografică

Steven M. Colegate, Russell J. Molyneux

Descriere

Following the successful format of the original, this new edition presents applications of the most recent techniques for the detection, isolation, and structural determination of bioactive natural products. It features new case studies and illustrations that demonstrate applications of techniques covered in the book. Complementing as much as replacing the first edition, most of the contributors are new. The text includes updates on chemical extraction, and NMR-based structure determination, and new contributions on liquid chromatography linked with mass and NMR spectroscopy, dereplication approaches, assessment of source material for natural products and novel bioassay development.