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Biochemistry of Antibodies

Autor R. Nezlin
en Limba Engleză Paperback – 19 mar 2012
When the history of immunology in the twentieth century is written, the decade of the 1960's will, in all probability, stand out as the period of greatest advance in the development of molecular immunology. It is appropriate and useful, therefore, that a schol­ arly and integrated presentation of this progress should be made available in English. The translation of Dr. Nezlin's "Biochem­ istry of Antibodies" from Russian admirably fulfills this need in the form of a scientific monograph directed to medical and biolog­ ical scientists. The appearance of this monograph also serves to emphasize the conceptual unification of diverse immunological phenomena which has emerged from progress in molecular immunology. This unity is a consequence of the key role played by the antibody mol­ ecule (either in solution or cell-bound) in every biological process properly described as immunological. Indeed, immunology as an independent natural science can be described as the study of the structure, interactions, and biosynthes is of the antibody molecule.
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Specificații

ISBN-13: 9781468417937
ISBN-10: 1468417932
Pagini: 404
Ilustrații: XIII, 381 p.
Dimensiuni: 152 x 229 x 21 mm
Greutate: 0.54 kg
Ediția:Softcover reprint of the original 1st ed. 1970
Editura: Springer Us
Colecția Springer
Locul publicării:New York, NY, United States

Public țintă

Research

Cuprins

I. Quantitative Methods for Determination of Antibodies.- Heidelbergern Quantitative Precipitation Method.- Quantitative Determination of Antibodies with the Aid of Immunoadsorbents.- Equilibrium Dialysis for the Quantitativ Measurement of the Hapten—Antibody Reaction.- Fluorescence Methods for Antibody Determination.- Literature Cited.- II. Isolation of Pure Antibodies.- Nonspecific Methods.- Specific Methods.- Isolation of Antibodies with the Aid of Fixed Antigens (Synthetic Immunoadsorbents).- Literature Cited.- III. Properties of Antibodies.- The Chief Types of Immunoglobulins.- Size and Shape of Molecules.- Molecular Weight.- Electrophoretic Properties.- Optical Properties.- Chemical Properties.- Valence of Antibodies.- Antigen Properties.- Heterogeneity of Antibodies.- Literature Cited.- IV. The Structure of Antibodies.- Fragments Obtained by Proteolytic Cleavage of Immunoglobulins.- Subunits and Peptide Chains Obtained by Chemical Treatment of Molecules of Immunoglobulins and Antibodies.- The Antibody Binding Site.- Literature Cited.- V. Antibody Biosynthesis.- The Fate of Antigen.- In Which Organs and Cells Are Antibodies Synthesized?.- Antibody-Synthesizing Cells.- RNA Synthesis in Lymphoid Cells during Antibody Synthesis.- Attempts to Induce Antibody Synthesis by RNA Fractions Isolated from Lymphoid Tissue of Immune Rabbits.- Dynamics of Antibody Synthesis.- In Vitro Antibody Synthesis.- Participation of Ribosomes in the Biosynthesis of Antibodies. Cell Free Systems Polyribosomes.- Inhibitors of Antibody Synthesis.- Literature Cited.- VI. Genetic Aspects of Antibody Synthesis.- Effect of Hereditary Factors on Synthesis of ?-Globulins and Antibodies.- Genetically Controllable Antigenic Determinants of Immunoglobulins (Allotypes).- Genes Controlling AntibodySynthesis.- Synthesis of DNA by Lymphoid Cells and Its Stimulation.- Literature Cited.- VII. Theory of Antibody Synthesis.- Template Theory of Antibody Synthesis.- Theory of the Pre-existence of Information for Antibody Specificity.- Theory of Repression—Derepression.- Evolutionary Aspects of Antibody Synthesis.- Literature Cited.