Biochemistry (Oklahoma Notes) de Thomas Briggs

Thomas Briggs

Albert M. Chandler

Since 1975, when the University of Oklahoma faculty created their review course for second-year medical students, the Oklahoma Notes have been among the most trusted and widely used reviews for the National Boards.
Each Oklahoma Notes book presents the core information of one segment of the medical school curriculum. Written by some of the most effective medical educators in the country, and now thoroughly updated and revised, the Oklahoma Notes feature: Concise text presented in outline format for rapid review; contents oriented to promote Boards success; self-assessment questions geared to the current format of the USMLE exam; more tables and figures designed to facilitate self-assessment and review; and low-cost, complete coverage of all subjects taught in the first two years of medical school.

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Cuprins

1. Amino Acids and Proteins.- Amino Acids.- Protein Structure: General.- Collagen and Fibrous Proteins.- Hemoglobin.- Plasma Proteins.- Hemostasis and Blood Coagulation.- Genetic Diseases.- Review Questions on Amino Acids and Proteins.- 2. Enzymes.- Nature of Enzymes.- Enzyme Kinetics.- Effects of Kinetic Parameters on Enzyme Activity.- General Aspects.- Review Questions on Enzymes.- 3. Carbohydrates.- Structural Aspects of Carbohydrates.- Digestion.- Glycolysis.- Entry of Other Hexoses into the Glycolytic Pathway.- Metabolism of Pyruvate.- Regulation of Glycolysis.- Pentose Phosphate Pathway.- Gluconeogenesis.- Glycogen Metabolism.- Glycogen Storage Diseases.- Hormonal Regulation of Carbohydrate Metabolism.- Review Questions on Carbohydrates.- 4. Energetics and Biological Oxidation.- Concepts in Biological Oxidation.- Metabolism of Pyruvate to Carbon Dioxide.- Electron Transfer via the Respiratory Chain.- Chemi-Osmotic Theory of Oxidative Phosphorylation.- Review Questions on Energetics and Biological Oxidation.- 5. Amino Acid Metabolism.- Functions of Amino Acids in Man.- Essential and Non-Essential Amino Acids.- Nitrogen Balance.- Protein Quality.- Protein Digestion.- Amino Acid Absorption.- Amino Acid Degradation.- The Urea Cycle (Krebs-Henseleit Cycle).- Excretion of Free Ammonia.- Degradation of the Carbon Skeletons.- One-Carbon Fragment Metabolism.- Metabolism of Phenylalanine and Tyrosine.- General Precursor Functions of Amino Acids.- Review Questions on Amino Acid Metabolism.- 6. Porphyrins.- Structure and Chemistry.- Metabolism.- Disorders of Porphyrin and Heme Metabolism.- Genetic Diseases.- Review Questions on Porphyrins.- 7. Lipids.- Classification of Lipids.- Functions of Lipids.- Digestion and Absorption of Lipids.- Fatty Acids.- Ketone Bodies.- Triacylglycerols.- Phospholipids.- Glycosphingolipids (Glycolipids).- Lipoproteins.- Genetic Diseases.- Review Questions on Lipids.- 8. Steroids.- Cholesterol: Structure and Chemistry.- Occurrence and Function.- Biosynthesis of Cholesterol.- Metabolism of Cholesterol.- Action of Steroid Hormones.- Cholesterol Levels.- Disorders of Cholesterol and Steroid Metabolism.- Cholesterol in Perspective.- Review Questions on Steroids.- 9. Membranes.- Overview.- Chemistry and Structure.- Functions.- Review Questions on Membranes.- 10. Nutrition.- Major Nutrients.- Micronutrients.- Review Questions on Nutrition.- 11. Purines and Pyrimidines.- Structure and Nomenclature.- Synthesis of Nucleoside Diphosphates and Triphosphates.- Purine Metabolism.- Pyrimidine Metabolism: Biosynthesis.- Deoxyribonucleotides Are Formed by Reduction of Ribonucleoside Diphosphates by Ribonucleoside Diphosphate Reductase (Ribonucleotide Reductase).- Some Anticancer Drugs Act by Blocking Deoxythmidylate Synthesis.- Functions of Nucleotides.- Review Questions on Purines and Pyrimidines.- 12. Nucleic Acids: Structure and Synthesis.- DNA.- RNA.- Review Questions on Nucleic Acids.- 13. Protein Biosynthesis.- Cellular Machinery.- Information Transfer.- Peptide Bond Formation.- Postribosomal Modification of Proteins.- Some Antibiotics Acting as Inhibitors of Protein Synthesis.- Review Questions on Protein Biosynthesis.- 14. Medical Genetics.- Basic Genetics.- Mutations.- Recombinant DNA Techniques.- Genetic Diagnostic Techniques.- Gene Therapy.- Well-Known Genetic Diseases.- Review Questions on Medical Genetics.