Biomedical Micro– and Nanorobots in Disease Treatment – Design, Preparation, and Applications

Chun Mao is Professor and Deputy Director at National and Local Joint Engineering Research Center of Biomedical Functional Materials, and he works in School of Chemistry and Materials Science, Nanjing Normal University, China. His research interests include biomedical functional materials, micro/nanoscience and technology, and the diagnosis and treatment of diseases. Mimi Wan obtained her Ph.D. in the Department of Chemistry at Nanjing University, China, in 2015. Currently she is a researcher at Jiangsu Key Laboratory of Biofunctional Materials, at Nanjing Normal University, China. In recent years, she has been engaged in the construction of biomedical functional materials (including mesoporous materials, micro/nanomotors, etc.) and applied them to the treatment of blood-related diseases.

INTRODUCTION Origin of Biomedical Micro- and Nanorobot A Long Journey Moment of Glory Three Laws Main Content of this Book DEFINITION AND CLASSIFICATION Definition Classification DESIGN AND PREPARATION Substrate Selection Driving System CHARACTERIZATION Motion Characterization In Vivo Tracking Technologies BIOSAFETY Biosafety of Micro- and Nanorobot Substrate Biosafety of Driving System of Micro- and Nanorobots Biosafety of Autonomous Motion Behavior of Micro- and Nanorobots Biosafety Evaluation Methods for Micro- and Nanorobots AUTONOMOUS MOTION BEHAVIOR Autonomous Motion Mechanism Trend Behavior Mechanism Motion Control FUNCTIONS Moving in Complex Physiological Environment Loading Power Source, Drug or Imaging Agent Targeting Specific Cells or Physiological Tissues Promoting Cell Uptake and Improving Tissue Permeability Imaging Capability Information Interaction and Intelligent Decision Diagnosis and Treatment of Disease FOR CARDIOVASCULAR DISEASE TREATMENT Thrombus Atherosclerosis Cerebral Apoplexy FOR CANCER TREATMENT Cancer Diagnosis Targeting and Delivery Treatment of Different Cancer Species Treatment Mechanism Theranostics FOR OTHER DISEASES TREATMENT Ophthalmic Disease Orthopedic Diseases Gastrointestinal Diseases Neurological Diseases Bacterial Infection Blood Heavy Metal Poisoning FUTURE DEVELOPMENT TREND Biosafety of Micro- and Nanorobots New Materials and Technologies of Micro- and Nanorobots Intelligent Micro- and Nanorobots New Treatment Mode New Detection Technology for Micro- and Nanorobots Outlook and Future Challenges