Quick-witted Ruby and her gorgeous, vampire boyfriend Simon leave the warm beaches of Florida and return to New Orleans, only to discover that someone is trying to kill her best friend Ambrosia. Since they've been gone, devious Edgar has taken over the local vampires in the aftermath of Roderick's death; he's gone power-mad with plans on exposing vampires to the world. Meanwhile, Desiree has traveled halfway across the globe, searching for an ancient secret and in the process uncovering the most deadly vampire legend of all. It's up to Ruby and Simon to save Ambrosia, shut down Edgar's insane plan, and survive the dormant horror that Desiree has awakened.