After a night she cannot remember, Abby awakens as a vampire. With insatiable urges she needs to satisfy, she decides to visit some ex-boyfriends. Unbeknownst to Abby, these ex-boyfriends turn up dead. In the meantime, Abby is attempting to re-connect with Seth, her ex-lover whom she jettisoned from her life a year earlier. Seth has moved away and is attempting, unsuccessfully, to meet his next Abby through online dating. Abby is questioned by detectives and soon becomes their primary suspect. Abby, knowing she has harmed no one, ignores the detectives dogged questioning, until she is arrested for multiple murders. Although Seth has been rejecting Abby's advances, Abby believes Seth, an attorney, is the only person who can help her. Seth, who professes his utter contempt for Abby for what she did to him, but secretly still loves her, agrees to represent her. At the same time, a local reporter has written an article that professes to be an interview with an actual vampire. When the reporter's life begins to spiral out of control due to the backlash from her article, she too looks to Seth for help. Unbeknownst to Seth, he is now representing two female vampires. Bloodography takes you through the myriad problems Seth runs into in his defense of vampires while a perceived vampire scourge is wreaking havoc across the country.