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Body-on-a-Chip: Essentials and Applications de Anthony Atala

Body-on-a-Chip: Essentials and Applications

Editat de Anthony Atala, J. Shrike Zhang
en Limba Engleză Hardback – noi 2025
Body-on-a-Chip: Essentials and Applications provides the reader high-quality information, in a single resource, that is necessary to explore the use of BOC systems from design and development to testing and personalized medicine, to medical research and diagnostics. BOC systems can recapitulate native tissue/ organ architecture, diffusion kinetics of drugs physiological flow conditions etc., similar to what would happen in the body, they are particularly powerful in predicting human efficacy prior to clinical testing of a drug, determining potential toxicity, or in clinical studies to test underlying mechanisms or action or adverse effects.

With recent advancements in high-throughput analysis systems and artificial intelligence, it has also become possible to screen several drugs at a time.


  • Covers design, applications, and future of this new generation technology
  • Provides a valuable resource for students, educators, scientists/researchers, and clinicians to use for education, research and exploring real world scenarios
  • Written by the world’s most prominent experts in the field
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Specificații

ISBN-13: 9780443161100
ISBN-10: 0443161100
Pagini: 500
Dimensiuni: 216 x 276 mm
Editura: ELSEVIER SCIENCE

Cuprins

1. The Concept of Organ-on-a-Chip and Body-on-a-Chip Devices
2. Advances in Three-Dimensional Cell Culture
3. Organoids and Spheroids
4. Microfluidics
5. Materials for fabricating Micro-physiological Systems
6. Design and Engineering of Multi-organ Systems
7. Recent Trends in Microfluidic Platforms for Body-on-a-chip systems
8. Chapter Microfabrication Techniques for Making Organ-on-a-Chip and Body-on-a-Chip Devices
9. Combining 3D bioprinting with organ-on-a-chip technology
10. Incorporating Biological Components within Organ-on-a-Chip and Body-on-a-Chip Systems
11. On-chip Sensing and Data Analysis from Multi-organ Systems
12. Liver-on-a-chip
13. Lung-on-a-chip
14. Lung-on-a-chip As a Model for Studying Effects of Cigarette Smoke
15. Kidney-on-a-chip
16. Adrenals-on-a-Chip
17. Heart-on-a-chip
18. Pancreas-on-a-Chip
19. Spleen-on-a-Chip
20. Skin-on-a-Chip
21. Blood Vessels-on-a-Chip
22. Bone-on-a-Chip
23. Cartilage-on-a-Chip
24. Muscle-on-a-Chip
25. Bladder-on-a-Chip
26. Testis-on-a-Chip
27. Ovary-on-a-chip
28. Thyroid-on-a-Chip
29. Thymus-on-a-Chip
30. Brain-on-a-Chip
31. Salivary glands-on-a-Chip
32. Bone marrow on a Chip
33. Human Organ-on-a-Chip Models for Diseases
34. Cancer-on-a-Chip
35. Modeling Disease Pathogenesis Using Organ-on-a-chip Platforms
36. Organ-on-a-chip using stem cells
37. Role of Body-on-a-chip Technology in Drug Discovery and Development
38. Computational Pharmacokinetic Modeling of Body-on-chip Devices
39. Drug and Toxicity Screening Using Multi-organ Systems
40. Micro-physiological Systems for Screening Environmental Toxins and Pollutants
41. Challenges in Manufacturing and Commercial Use of Body-on-a-chip and other Micro-physiological Devices
42. Body-on-chip Devices and the Regulatory Agencies
43. Body-on-chip Systems and Clinical Biomarkers Discovery
44. Body-on-chip Systems and chemical agents
45. Body-on-chip Systems and viral agents
46. Body-on-chip Systems and omics
47. Body-on-chip Systems and artificial intelligence- pathways for the future