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Bradykinin: From Vasodilation to Neuroinflammation: Molecular Mediators in Health and Disease: How Cells Communicate

Editat de Réjean Couture
en Paperback – 5 mai 2025
Bradykinin: From Vasodilation to Neuroinflammation is a complete guide to this multi-functional peptide, and its impact across the human body. Early chapters provide an overview of the biosynthesis and metabolism of bradykinin, understanding of its receptors and signaling pathways, and the therapeutic value of agonists and antagonists for targeting these. Bradykinin: From Vasodilation to Neuroinflammation explores the role of bradykinin in vascular, renal and brain function, as well as influence on various conditions and diseases, including inflammation, pain, cardiovascular disease, renal disease, obesity, ischemic stroke, and infectious disease, including Covid-19. This is a volume in the Molecular Mediators in Health and Disease series. This book includes extensive coverage of bradykinin biochemistry and molecular biology, as well as therapeutic potential of bradykinin, and is an ideal reference for researchers working across these fields.

  • Explores the communication role of bradykinin in both homeostasis and pathologic states
  • Investigates bradykinin across various conditions, including cardiovascular and renal disease, heart failure, diabetes and cancer
  • Discusses bradykinin receptors and their signalling pathways
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Specificații

ISBN-13: 9780443289071
ISBN-10: 0443289077
Pagini: 400
Dimensiuni: 191 x 235 mm
Editura: ELSEVIER SCIENCE
Seria Molecular Mediators in Health and Disease: How Cells Communicate


Cuprins

1. Introduction
2. Biosynthesis and metabolism of bradykinin
3. Bradykinin receptors and their signalling pathways
4. Animal models for studying bradykinin receptors
5. Peptide and non-peptide ligands acting at bradykinin receptors
6. Bradykinin in angioedema
7. Bradykinin and its receptors in inflammation
8. Bradykinin in Pain
9. Bradykinin in cardiovascular and renal diseases
10. Bradykinin in hypertension and heart failure
11. Bradykinin and its receptors in neovascularisation
12. Bradykinin in diabetes and obesity
13. Bradykinin in ocular diseases
14. Bradykinin agonists as a mean to increase blood-brain barrier permeability
15. Bradykinin as a central mediator
16. Bradykinin in infectious and parasitic diseases
17. Bradykinin in cancer