Cambodia has established itself as a global leader in the fight against HIV/AIDS, cutting adult infection rates in the general population by more than half in the past 14 years and providing HIV treatment to over 80 percent of eligible individuals since services were established in 2003. The U.S. government (USG) contributed substantially to Cambodia's achievements, historically providing almost 40 percent of the financial resources behind the national response and establishing the surveillance, service delivery, and quality-assurance platforms needed for achievement of national goals as well as the objectives of investments by the Global Fund to Fight AIDS, Tuberculosis and Malaria (Global Fund), other donors, and the Royal Government of Cambodia. Against the backdrop of a global financial crisis; a persistent, concentration of HIV in high-risk groups; competing health and development priorities; and emerging innovations in HIV prevention, the Cambodian government and its development partners are adapting to a changing resource and epidemiological context in order to maintain and further advance Cambodia's status as a leader in the global fight against HIV.