This document presents the results of surface-water-quality data retrievals for Cape Lookout National Seashore (CALO) from six of the United States Environmental Protection Agency's (EPA) national databases: (1) Storage and Retrieval (STORET) water quality database management system; (2) River Reach File (RF3); (3) Industrial Facilities Discharge (IFD); (4) Drinking Water Supplies (DRINKS); (5) Flow Gages (GAGES); and (6) Water Impoundments (DAMS). This document is one product resulting from a cooperative contractual endeavor between the National Park Service's Servicewide Inventory and Monitoring Program, the National Park Service's Water Resources Division (WRD), and Horizon Systems Corporation to retrieve, format, and analyze water quality data for all units of the National Park System containing significant water resources.