Carbohydrate–Based Therapeutics de R Adamo

Carbohydrate–Based Therapeutics

R Adamo

The book covers current progress and opens new frontiers in carbohydrate-based therapeutic applications. It presents a detailed background of the diseases coupled with the subsequent carbohydrate-based therapies. This aspect renders this book unique and will serve as a quick reference practical book of carbohydrate applications. The link between chemistry and design of novel carbohydrate-based medicines is highlighted and broad overview of all the potential applications of carbohydrates is given. Emphasis is laid on concepts used for carbohydrate drug design, structure-activity relationship and impact on health and diseases.

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Notă biografică

Roberto Adamo joined Novartis Vaccines in 2007 where he was later appointed Head of the Carbohydrate Chemistry Laboratory, and Leader of the Conjugation & Synthesis Platform. After the GSK acquisition of the company he became Preclinical Representative Leader of the Conjugation Platform. He is currently Technology and Project Leader at GSK, Italy. His research focuses on the synthesis of glycans, glycoconjugates and glyconanoparticles to be used for carbohydrate-based therapeutics. He has over 70 publications in the field including a book. He is the Associate editor of the Glycoconjugate Journal. Luigi Lay is full professor at the Department of Chemistry of the University of Milan. His research interests are focused on carbohydrate chemistry and the use of synthetic glycans to investigate their biological properties. He is author of 86 publications in the field and some book chapters.

Cuprins

PART I ANTIMICROBIAL CARBOHYDRATE BASED THERAPIES Antibacterial Vaccines Antiviral Vaccines Antifungal Therapies Anti Influenza Therapeutics Antiadhesive Carbohydrates and Glycomimetics PART II ANTI CANCER CARBOHYDRATE-BASED THERAPIES Cancer Vaccines and Immunotherapy Carbohydrate Tools in Cancer Biology Carbohydrates and Glycoconjugates in Autophagy Lectin Ligands to Target Cancer PART III CARBOHYDRATE-BASED THERAPIES IN METABOLIC, NEURONAL AND IMMUNE DISORDERS Carbohydrate-Based Therapeutics for Lysosomal Disorders Carbohydrate-Based Therapeutics for Neurodegenerative Diseases Carbohydrate-Based Antithrombotics Glycans and Blood Types Carbohydrate-Based Therapeutics for Autoimmune Diseases N-Glycosylation of Antibodies and Immunity Type 1 Diabetes PART IV NEW FRONTIERS IN CARBOHYDRATE-BASED THERAPIES Carbohydrates for Tissue Engineering Antiangiogenic and Regenerative Medicine Carbohydrate-Based Therapeutics for Bowel Diseases