Carbonic Anhydrases: Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target
Editat de Claudiu T. Supuran, Alessio Nocentinien Limba Engleză Paperback – 18 iul 2019
Carbonic Anhydrases provides biology, biochemistry, and medicinal chemistry students and researchers a thorough discussion and update on the evergreen and expanding research area of CAs.
- Offers a full overview of CAs’ biochemical and structural features, as well as drug design and pharmacology of inhibitors and activators
- Provides a thorough update on the newly identified isoforms, modulating chemotypes, and innovative biomedical applications
- Describes the current biotechnological applications of CAs, including processes for CO2 capture
- Features chapter contributions from international leaders in CA biology, medicinal chemistry, and pharmacology
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Specificații
ISBN-13: 9780128164761
ISBN-10: 012816476X
Pagini: 560
Ilustrații: 50 illustrations (20 in full color)
Dimensiuni: 191 x 235 mm
Editura: ELSEVIER SCIENCE
ISBN-10: 012816476X
Pagini: 560
Ilustrații: 50 illustrations (20 in full color)
Dimensiuni: 191 x 235 mm
Editura: ELSEVIER SCIENCE
Public țintă
Active researchers and students in biochemistry, molecular biology, pharmaceutical science, cellular biology, applied microbiology, and biotechnology; medical chemists; clinician scientistsCuprins
1. Carbonic Anhydrases: An Overview
2. α-Carbonic Anhydrases
3. β-Carbonic Anhydrases
4. γ-Carbonic Anhydrases
5. δ-Carbonic Anhydrases
6. ζ-Carbonic Anhydrases
7. η and θ-Carbonic Anhydrases
8. Human Carbonic Anhydrases: Tissue Distribution, Physiological Role and Druggability
9. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Zinc Binders
10. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds That Anchor to The Zinc-Bound Nucleophile
11. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds Occluding the Entrance of The Active Site
12. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds That Bind “Out of The Binding Site And Compounds with An Unknown Mechanism of Action
13. Carbonic Anhydrase Inhibitors as Ophthalmologic Drugs for The Treatment of Glaucoma
14. Carbonic Anhydrase Inhibitors as Diuretics
15. Carbonic Anhydrase Inhibitors for The Treatment of Epilepsy and Obesity
16. Carbonic Anhydrase Inhibitors for The Treatment of Tumors: Therapeutic, Immunologic, And Diagnostic Tools Targeting Isoforms IX And XII
17. Carbonic Anhydrase Inhibitors for The Treatment of Neuropathic Pain and Arthritis
18. Carbonic Anhydrases from Pathogens: Bacterial Cas And Their Inhibitors as Potential Anti-Infectives
19. Carbonic Anhydrases from Pathogens: Fungal Cas And Their Inhibitors as Potential Antifungal Agents
20. Carbonic Anhydrases from Pathogens: Protozoan Cas And Related Inhibitors as Potential Anti-Protozoal Agents
21. Carbonic Anhydrase Activators and Their Potential in The Pharmaceutical Field
22. Biotechnological Applications of Carbonic Anhydrases from Extremophiles
23. CO2 Capture by Engineered Mammalian Carbonic Anhydrases
2. α-Carbonic Anhydrases
3. β-Carbonic Anhydrases
4. γ-Carbonic Anhydrases
5. δ-Carbonic Anhydrases
6. ζ-Carbonic Anhydrases
7. η and θ-Carbonic Anhydrases
8. Human Carbonic Anhydrases: Tissue Distribution, Physiological Role and Druggability
9. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Zinc Binders
10. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds That Anchor to The Zinc-Bound Nucleophile
11. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds Occluding the Entrance of The Active Site
12. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds That Bind “Out of The Binding Site And Compounds with An Unknown Mechanism of Action
13. Carbonic Anhydrase Inhibitors as Ophthalmologic Drugs for The Treatment of Glaucoma
14. Carbonic Anhydrase Inhibitors as Diuretics
15. Carbonic Anhydrase Inhibitors for The Treatment of Epilepsy and Obesity
16. Carbonic Anhydrase Inhibitors for The Treatment of Tumors: Therapeutic, Immunologic, And Diagnostic Tools Targeting Isoforms IX And XII
17. Carbonic Anhydrase Inhibitors for The Treatment of Neuropathic Pain and Arthritis
18. Carbonic Anhydrases from Pathogens: Bacterial Cas And Their Inhibitors as Potential Anti-Infectives
19. Carbonic Anhydrases from Pathogens: Fungal Cas And Their Inhibitors as Potential Antifungal Agents
20. Carbonic Anhydrases from Pathogens: Protozoan Cas And Related Inhibitors as Potential Anti-Protozoal Agents
21. Carbonic Anhydrase Activators and Their Potential in The Pharmaceutical Field
22. Biotechnological Applications of Carbonic Anhydrases from Extremophiles
23. CO2 Capture by Engineered Mammalian Carbonic Anhydrases