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Catecholamines and Behavior · 2: Neuropsychopharmacology

Autor Arnold J. Friedhoff
en Limba Engleză Paperback – 6 apr 2012
This volume is intended to provide students and investigators of brain-be­ havior relationships with an understanding of the current concepts of the role of catecholamines in the regulation of behavior. Catecholamines are now believed to be modulators or transmitters in systems regulating a number of important aspects of behavioral function. The present intense interest in catecholamines is reflected by the large number of scientific reports dealing with these compounds. Even those reports which are rele­ vant to behavior are staggering in number. The contributors to this book have drawn on the salient literature, as well as on their own work, with a view toward clarifying relationships between the basic neurobiology of cate­ cholaminergic neural systems and normal and abnormal behavioral func­ tion. Current work in this field is heavily dependent on the use of psychotropic drugs to produce model behavioral states, or as biological probes. As a result psychopharmacological studies are generously represented. I n the last chapter of Volume 2 the editor has attempted to further relate and develop the material in the two volumes from the con­ ceptual and theoretical standpoint. New York AJF Contributors to Volume 2 Wagner H. Bridger, Department oj Psychiatry, Albert Einstein College oj Medicine, Bronx, New York Thomas R. Bozewicz, Department oj Psychiatry, Albert Einstein College oj Medicine, Bronx, New York Doris H. C1ouet, Testing and Research Laboratory, New York State Drug Abuse Control Commission, Brooklyn, New York John M.
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Specificații

ISBN-13: 9781468431407
ISBN-10: 1468431404
Pagini: 244
Ilustrații: XIII, 225 p. 2 illus.
Dimensiuni: 152 x 229 x 13 mm
Greutate: 0.33 kg
Ediția:Softcover reprint of the original 1st ed. 1975
Editura: Springer Us
Colecția Springer
Locul publicării:New York, NY, United States

Public țintă

Research

Cuprins

1 The Role of Catecholamines in Animal Learning and Memory.- 1. Definitions.- 2. Problems of Specificity.- 3. Experimental Approaches 6.- 4. CA as Independent Variable 6.- 5. Behavior as Independent Variable 19.- 6. Conclusions.- 7. References.- 2 Stress and Catecholamines.- 1. Introduction.- 2. Tissue Levels of Norepinephrine and Dopamine.- 3. Turnover.- 4. Metabolites.- 5. Functional Significance.- 6. References.- 3 The Catecholamines: Possible Role in Affect, Mood, and Emotional Behavior in Man and Animals.- 1. Introduction.- 2. Catecholamines and Affect: Historical Perspectives.- 3. Catecholamines and Affect: Methodologic Issues in Human and Animal Studies.- 4. Affect-Related Behavior Resulting from the Administration of Catecholamines and Catecholamine-Altering Drugs.- 5. Alterations in Catecholamine Metabolism Resulting from Affect-Related Behavior.- 6. Interrelationships between Affects and Psychomotor Activation: A Reevaluation of the Role of Catecholamines in Affect-Related Behavior.- 7. Summary.- 8. References.- 4 Catecholamines and Depression: A Further Specification of the Catecholamine Hypothesis of the Affective Disorders.- 1. Introduction.- 2. Metabolism of Norepinephrine.- 3. MHPG in Affective States.- 4. Subgroups of Depression.- 5. Biochemical Mechanisms in Affective Disorders.- 6. Summary.- 7. References.- 5 Catecholamines and Psychosis.- 1. Introduction.- 2. Dopamine Theory of Schizophrenia.- 3. Amphetamine Psychosis as a Model.- 4. Mechanism of Amphetamine Psychosis.- 5. Transmitter Balance.- 6. Two-Factor Theory of Schizophrenia.- 7. References.- 6 Serum Dopamine-?-Hydroxylase in Various Pathological States.- 1. Introduction.- 2. Determination of D?H Activity in Human Serum.- 3. Determination of Immunoreactive (IR) D?H Levels in Human Serum.- 4.Serum D?H Levels: Enzymatic Assay Versus Radioimmunoassay.- 5. Serum D?H Activity in Neuroblastoma.- 6. Serum D?H Activity in Familial Dysautonomia.- 7. Serum D?H Levels in Down’s Syndrome.- 8. Serum D?H Activity in Affective States.- 9. Discussion and Conclusions.- 10. References.- 7 Possible Roles of Catecholamines in the Action of Narcotic Drugs.- 1. Introduction.- 2. Effects of Other Drugs on Opiate Activity.- 3. Opiate-Induced Alterations in the Levels of Brain Catecholamines.- 4. Opiate-Induced Alterations in the Turnover of Brain Catecholamines.- 5. Effects of Opiates on the Transport of Catecholamines.- 6. Effects of Opiates on the Adenyl Cyclase System in Brain.- 7. Dopamine Receptor Hypothesis.- 8. Discussion and Conclusions.- 9. References.- 8 Metabolic Adaptation to Antidepressant Drugs: Implications for Pathophysiology and Treatment in Psychiatry.- 1. Biochemical Indices of Psychotropic Drug Action.- 2. Adaptive Mechanisms in Central Synapses.- 3. Enzymatic Adaptation to Chronic Drug Administration.- 4. A Model for Neurochemical Adaptation to Tricyclic Drugs.- 5. A Revised Theory of Depressive Illness.- 6. References.- 9 Integration and Conclusions.- 1. Introduction.- 2. Research Strategies.- 3. Determinants of Behavior.- 4. Conceptual Models for the Multiple Roles of Catecholamines in Brain.- 5. New Conceptual Models of Psychopathological States.- 6. Development of New Treatments.- 7. Directions for Future Research.