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CCK (Cholecystokinin): From Gallbladder to Cognition and Beyond: Molecular Mediators in Health and Disease: How Cells Communicate

Editat de Christine Feinle-Bisset, Jens F Rehfeld
en Limba Engleză Paperback – 7 apr 2025
CCK (Cholecystokinin): From Gallbladder to Cognition and Beyond covers the biology and pathophysiological roles of cholecystokinin (CCK) peptides in the human body. It begins with a historical overview before delving into the biology of CCK, from biogenesis to cell expression and receptor function. CCK phylogenesis is also explored across various species including fish, birds, insects and amphibians. The physiology of CCK is also examined, including its role in motor function, appetite. the gallbladder and pancreas, The book moves on to CCK in various diseases, including metabolic diseases, tumors and psychiatric illness. The latest advances in its use for management of obesity and pain are also investigated.

CCK (Cholecystokinin): From Gallbladder to Cognition and Beyond is a volume in the Molecular Mediators in Health and Disease book series, and acts as a fundamental reference on all biological and clinical aspects of CCK. This book is ideal for researchers interested in learning more about the role of CCK and its impact across health and disease.

  • Investigates the communication role of CCK in cerebral functions, homeostasis, and pathologic states
  • Explores CCK across a range of medical conditions, including type 2 diabetes, tumors, gut-brain interaction, nociception and cerebral disease
  • Considers the latest developments in CCK-based therapeutic approaches and future directions for CCK research
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Specificații

ISBN-13: 9780443237201
ISBN-10: 0443237204
Pagini: 450
Dimensiuni: 191 x 235 mm
Editura: ELSEVIER SCIENCE
Seria Molecular Mediators in Health and Disease: How Cells Communicate


Cuprins

Part I History 1. Milestones in the CCK history Part II Biology of CCK 2. The CCK phylogenesis - Including other animals (fish, starfish, other species) 3. CCK biogenesis and cell-specific expression of CCK peptides 4. CCK in intestinal and extraintestinal endocrine cells 5. CCK in cerebral and peripheral neurons 6. CCK1 and CCK2 receptors 7. The relationship of CCK and gastrin Part III Physiology of CCK 8. Intestinal CCK secretion 9. CCK and the vagus – gut-brain axis 10. CCK and the gallbladder 11. CCK and the exocrine pancreas (including pancreatitis, pancreatic cancer) 12. CCK and the endocrine pancreas, including T2 diabetes 13. CCK and GI motor function – oesophagus to colon 14. CCK and appetite/food intake 15. CCK and food/nutrient preferences (including conditioned flavour preferences) 16. CCK and nausea/taste aversion 17. CCK and peripheral and central cardiovascular control 18. CCK in cardiac myocytes, including cardiac diseases Part IV Methods used for CCK research 19. CCK in circulation and how it is measured 20. CCK knockout mice: peripheral and central phenotypes Part V CCK in disease 21. CCK in metabolic diseases 22. CCK and disorders of gut-brain interaction (DGBIs; functional dyspepsia, IBS) 23. CCK in tumors 24. CCK and fear/anxiety, cerebral disease 25. CCK and the immune system 26. CCK and nociception Part V CCK-based novel therapeutic approaches 27. CCK and potential novel therapeutics Part VI Conclusion 28. Future directions for CCK research