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Cell Polarity in Development and Disease: Perspectives in Translational Cell Biology

Editat de Douglas W Houston
en Limba Engleză Paperback – noi 2017
Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the onset and progression of cancer. This book provides a basic resource for understanding the biology of polarity, offering a starting point for those thinking of targeting cell polarity for translational medical research.


  • Provides basic science understanding of cell polarity disease and development
  • Covers diseases affecting polarized epithelial tissues in the lung and kidney, also covering the progression of cancer
  • Includes historical context of cell polarity research for potential future breakthroughs
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Specificații

ISBN-13: 9780128024386
ISBN-10: 0128024380
Pagini: 236
Ilustrații: 75 full color
Dimensiuni: 152 x 229 x 27 mm
Editura: ELSEVIER SCIENCE
Seria Perspectives in Translational Cell Biology


Cuprins

1. Overview of cell polarity: insights from model organisms and cellular systems
2. Cell polarity in the egg and early embyro- mammal
3. Pluripotency and cell polarity
4. The role of cell polarity in adult stem cell maintenance
5. Integration of cell polarity and growth factor signaling
6. Cell polarity and the onset and progression of cancer
7. Cell division and cell polarity
8. Polarized membrane/vesicle trafficking and disease
9. Polarized microtubule transport and disease
10. Regulation of cell polarity in cell/neuronal migration
11. Apical and planar cell polarity in ciliated epithelia
12. Renal epithelial cell polarity and disease
13. Hepatic cell polarity and disease
14. Epidermal cell polarity and disease
15. Cell polarity and sensory cell defects