This is a comprehensive book that covers various aspects of chalcone including its chemical structure, reactivity, synthesis, and biological activities. The book explores the use of spectroscopy techniques such as X-ray diffraction, NMR, UV-Vis, IR, and fluorescence to study chalcone's structure and energy. Computational chemistry methods such as DFT and molecular modeling are also discussed in the book. The book focuses on the various biological activities of chalcone including its antioxidant, anti-inflammatory, antimicrobial, and anticancer properties. It explores the use of chalcone and its derivatives in medicinal chemistry and pharmacology. Structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) are also covered in the book. The book also discusses the various synthetic methods used to prepare chalcone and its derivatives including electrophilic substitution, nucleophilic addition, Michael addition, Claisen-Schmidt condensation, aldol condensation, and Robinson annulation. The use of heterocycles such as pyrazoline, thiophene, pyrimidine, pyridine, piperidine, imidazole, benzimidazole, indole, pyrazole, and isoxazole in the synthesis of chalcone derivatives is also explored. The book concludes with a discussion on the use of molecular docking studies in exploring the interactions of chalcone and its derivatives with biomolecules. In summary, "Chalcone Studies Structure and Energy" is an essential reference for researchers and students working in the field of chalcone and its derivatives.