The substituted chalcone and isoxazole are considered to be important synthons due to their versatility towards chemical transformations to useful synthetic intermediates as well as various biological activities. The book focuses on main aspects of chemical reaction, mechanism and applications of synthetic utility. The content is explained in an easy and simple language. It will be a good source of information about fundamental knowledge of organic synthesis of chalcones and isoxazoles as well as reaction path with mechanism to students at undergraduate level, post Graduate level, researchers as well as industrial chemist.