Chalcone is one of the most versatile scaffolds with wide range of applications. It is used as a precursor for diverse classes of organic molecules, natural flavonoids and possesses interesting biological activities and physical properties like semiconductor, non-linear optical, fluorescence, and electronic properties to name a few. Chalcones have been the subject of intense research due to their biological activities and the ability to tweak their biological activity and other properties by small changes along the a, b-unsaturated backbone. Besides their inherent biological activities, they have found uses in food industry and cosmetic industry as additives, due to their UV protection properties. They have also found applications as chemosensors and probes. These diverse features make chalcones one of the most fascinating molecules Chalcones and their Derivatives: From Synthesis to Applications features this molecule, different methods and approaches to synthesis, significance of this scaffold in biology, and other diverse fields. It serves as a comprehensive literature guide for researchers and a reference material for the postgraduate students involved with the development and use of chalcone based molecules.

• Addresses the lack of in-depth exploration in recent publications, offering a consolidated and holistic perspective on the scaffold's immense potential in various scientific domains
• Highlighting the chalcone scaffold's versatility, showcasing its role as a precursor for diverse organic molecules and its contribution to the synthesis of natural flavonoids
• Underlines the practical significance of chalcones in industries like food and cosmetics, thanks to their UV protection properties