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Chitosan: A natural solubility enhancer for simvastatin

Autor Seema Pattewar, Patil Deepak, Jadhav Ravindra
en Limba Engleză Paperback – 26 oct 2012
The enhancement of the oral bioavailability is currently one of the greatest challenges in the development of poorly water soluble drugs. The main objective of work to enhance solubility of Simvastatin (SIM) by use of natural polymer, chitosan (CHI) to produce cost effective formulation.Physical mixture, co-grinding method, spray drying method are compared.Co-grinding method applied for preparation of drug polymer complex and compared with the solubility and dissolution of marketed preparation.
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Specificații

ISBN-13: 9783659288418
ISBN-10: 3659288411
Pagini: 84
Dimensiuni: 152 x 229 x 5 mm
Greutate: 0.14 kg
Editura: LAP LAMBERT ACADEMIC PUBLISHING AG & CO KG
Colecția LAP Lambert Academic Publishing