This book focuses on persons with severe depression and formulates empathic, humanistic and effective interventions in dealing with severe depression. The NICHE approach described in this book is a prolonged and accumulative crystallisation of innovative ideas, successful interventions, genuine sharing and courageous trials in the process of clinical training and supervision. The acronym NICHE refers to normalised intervention; integrated intervention; communicating and sharing unresolved emotional complex of clients with severe depression; holistic and humane self assertion of clients with severe depression and evolving hope and meaningfulness for clients with severe depression.